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    NCAM2 neural cell adhesion molecule 2 [ Homo sapiens (human) ]

    Gene ID: 4685, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NCAM2provided by HGNC
    Official Full Name
    neural cell adhesion molecule 2provided by HGNC
    Primary source
    HGNC:HGNC:7657
    See related
    Ensembl:ENSG00000154654 MIM:602040; AllianceGenome:HGNC:7657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCAM21
    Summary
    The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 13.1), adrenal (RPKM 3.2) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCAM2 in Genome Data Viewer
    Location:
    21q21.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (20998409..21543329)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (19360795..19909385)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (22370727..22915650)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 1 Neighboring gene uncharacterized LOC124905057 Neighboring gene Sharpr-MPRA regulatory region 4841 Neighboring gene Sharpr-MPRA regulatory region 4883 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:22737134-22737706 Neighboring gene long intergenic non-protein coding RNA 317 Neighboring gene long intergenic non-protein coding RNA 1425

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition? Scholz C, et al. Eur J Med Genet, 2016 Oct. PMID 27596683
    2. Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy. Takahashi S, et al. Cancer Sci, 2011 Apr. PMID 21214674
    3. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. Paoloni-Giacobino A, et al. Genomics, 1997 Jul 1. PMID 9226371
    4. NCAM2/OCAM/RNCAM: cell adhesion molecule with a role in neuronal compartmentalization. Winther M, et al. Int J Biochem Cell Biol, 2012 Mar. PMID 22155300
    5. 21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders. Petit F, et al. Eur J Med Genet, 2015 Jan. PMID 25464110

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
      Title: NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
    2. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo.
      Title: Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo.
    3. These results reveal that the NCAM2 FnIII domains form a rigid structure that binds and activates FGFR in a manner related to, but different from NCAM1.
      Title: NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.
    4. Our reported case raises the questions whether the NCAM2-deletion is the true cause of the autism spectrum disorder or only a risk factor and whether there might be any connection in NCAM2 with skull-size
      Title: NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
    5. Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss.
      Title: Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.
    6. A complete structural model of the entire ectodomain of human NCAM2 has been assembled from crystal structures of six recombinant proteins corresponding to different regions of the ectodomain.
      Title: Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule.
    7. High NCAM2 is associated with increased 5-Fluorouracil sensitivity in prostate and breast cancer.
      Title: Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy.
    8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study on obesity and obesity-related traits.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
    EBI GWAS Catalog
    Joint influence of small-effect genetic variants on human longevity.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC51008

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule 2
    Names
    N-CAM-2
    NCAM-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001352591.2 → NP_001339520.1  neural cell adhesion molecule 2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001115, AP001137, AP001138, AP001252
      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (6) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:300 → 397
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    2. NM_001352592.2 → NP_001339521.1  neural cell adhesion molecule 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP001115, AP001136, AP001137, AP001138, AP001252
      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (6) summary
      cd05866
      Location:46 → 137
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:325 → 422
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:521 → 613
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:619 → 703
      fn3; Fibronectin type III domain
      pfam13927
      Location:426 → 504
      Ig_3; Immunoglobulin domain
      cl11960
      Location:233 → 326
      Ig; Immunoglobulin domain

    3. NM_001352593.2 → NP_001339522.1  neural cell adhesion molecule 2 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001137, AP001138, AP001252
      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (6) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:300 → 397
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    4. NM_001352594.2 → NP_001339523.1  neural cell adhesion molecule 2 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001137, AP001138, AP001252
      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (6) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:300 → 397
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    5. NM_001352595.2 → NP_001339524.1  neural cell adhesion molecule 2 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AK299054, AP001115, AP001137
      UniProtKB/TrEMBL
      B7Z5K2
      Conserved Domains (5) summary
      cd05870
      Location:158 → 255
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:354 → 446
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:452 → 536
      fn3; Fibronectin type III domain
      pfam13927
      Location:259 → 337
      Ig_3; Immunoglobulin domain
      cl11960
      Location:66 → 159
      Ig; Immunoglobulin domain

    6. NM_001352596.2 → NP_001339525.1  neural cell adhesion molecule 2 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AI500562, AP001137, AP001138, AP001252
      Conserved Domains (5) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:300 → 397
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:496 → 556
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    7. NM_001352597.2 → NP_001339526.1  neural cell adhesion molecule 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AK302870
      Conserved Domains (4) summary
      cd05866
      Location:46 → 137
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:325 → 422
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      pfam13927
      Location:147 → 212
      Ig_3; Immunoglobulin domain
      cl11960
      Location:233 → 326
      Ig; Immunoglobulin domain

    8. NM_004540.5 → NP_004531.2  neural cell adhesion molecule 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_004531.2

      Status: REVIEWED

      Source sequence(s)
      AI207079, AP001115, BC052946
      Consensus CDS
      CCDS42910.1
      UniProtKB/Swiss-Prot
      A8MQ06, B7Z841, O15394, Q7Z7F2
      UniProtKB/TrEMBL
      H9KV31
      Related
      ENSP00000383392.1, ENST00000400546.6
      Conserved Domains (8) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:300 → 397
      Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      smart00408
      Location:414 → 482
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:308 → 395
      IG_like; Immunoglobulin like
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:22 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      20998409..21543329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440785.1 → XP_047296741.1  neural cell adhesion molecule 2 isoform X6

      UniProtKB/TrEMBL
      H9KV31

    2. XM_024452081.2 → XP_024307849.1  neural cell adhesion molecule 2 isoform X7

      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (6) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:300 → 397
      Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    3. XM_011529575.4 → XP_011527877.1  neural cell adhesion molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_011527877.1

      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (8) summary
      cd05870
      Location:325 → 422
      IgI_NCAM-2; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 2 (NCAM-2)
      smart00408
      Location:153 → 214
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:521 → 613
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:619 → 703
      fn3; Fibronectin type III domain
      pfam13927
      Location:426 → 504
      Ig_3; Immunoglobulin domain
      cd00096
      Location:443 → 447
      Ig; Ig strand B [structural motif]
      cd05866
      Location:46 → 138
      IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
      cd20970
      Location:234 → 323
      IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains

    4. XM_047440784.1 → XP_047296740.1  neural cell adhesion molecule 2 isoform X2

      UniProtKB/TrEMBL
      H9KV31

    5. XM_011529581.4 → XP_011527883.1  neural cell adhesion molecule 2 isoform X4

      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (8) summary
      cd05866
      Location:46 → 137
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:325 → 422
      Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      smart00408
      Location:439 → 507
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:333 → 420
      IG_like; Immunoglobulin like
      cd00063
      Location:521 → 613
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:47 → 136
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:619 → 703
      fn3; Fibronectin type III domain
      cl11960
      Location:233 → 326
      Ig; Immunoglobulin domain

    6. XM_011529580.4 → XP_011527882.1  neural cell adhesion molecule 2 isoform X3

      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (8) summary
      cd05866
      Location:46 → 137
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:325 → 422
      Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      smart00408
      Location:439 → 507
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:333 → 420
      IG_like; Immunoglobulin like
      cd00063
      Location:521 → 613
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:47 → 136
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:619 → 703
      fn3; Fibronectin type III domain
      cl11960
      Location:233 → 326
      Ig; Immunoglobulin domain

    7. XM_011529582.4 → XP_011527884.1  neural cell adhesion molecule 2 isoform X5

      UniProtKB/TrEMBL
      H9KV31
      Conserved Domains (8) summary
      cd05866
      Location:46 → 137
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      cd05870
      Location:325 → 422
      Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      smart00408
      Location:439 → 507
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:333 → 420
      IG_like; Immunoglobulin like
      cd00063
      Location:521 → 613
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:47 → 136
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:619 → 703
      fn3; Fibronectin type III domain
      cl11960
      Location:233 → 326
      Ig; Immunoglobulin domain

    8. XM_017028356.3 → XP_016883845.1  neural cell adhesion molecule 2 isoform X8

      UniProtKB/TrEMBL
      B7Z5K2
      Conserved Domains (7) summary
      cd05870
      Location:136 → 233
      Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      smart00408
      Location:250 → 318
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:144 → 231
      IG_like; Immunoglobulin like
      cd00063
      Location:332 → 424
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:51 → 134
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:430 → 514
      fn3; Fibronectin type III domain
      cl11960
      Location:44 → 137
      Ig; Immunoglobulin domain

    9. XM_011529585.3 → XP_011527887.1  neural cell adhesion molecule 2 isoform X8

      See identical proteins and their annotated locations for XP_011527887.1

      UniProtKB/TrEMBL
      B7Z5K2
      Conserved Domains (7) summary
      cd05870
      Location:136 → 233
      Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
      smart00408
      Location:250 → 318
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:144 → 231
      IG_like; Immunoglobulin like
      cd00063
      Location:332 → 424
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:51 → 134
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:430 → 514
      fn3; Fibronectin type III domain
      cl11960
      Location:44 → 137
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      19360795..19909385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324515.1 → XP_054180490.1  neural cell adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      H9KV31

    2. XM_054324520.1 → XP_054180495.1  neural cell adhesion molecule 2 isoform X6

      UniProtKB/TrEMBL
      H9KV31

    3. XM_054324521.1 → XP_054180496.1  neural cell adhesion molecule 2 isoform X7

      UniProtKB/TrEMBL
      H9KV31

    4. XM_054324514.1 → XP_054180489.1  neural cell adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      H9KV31

    5. XM_054324516.1 → XP_054180491.1  neural cell adhesion molecule 2 isoform X2

      UniProtKB/TrEMBL
      H9KV31

    6. XM_054324518.1 → XP_054180493.1  neural cell adhesion molecule 2 isoform X4

      UniProtKB/TrEMBL
      H9KV31

    7. XM_054324517.1 → XP_054180492.1  neural cell adhesion molecule 2 isoform X3

      UniProtKB/TrEMBL
      H9KV31

    8. XM_054324519.1 → XP_054180494.1  neural cell adhesion molecule 2 isoform X5

      UniProtKB/TrEMBL
      H9KV31

    9. XM_054324523.1 → XP_054180498.1  neural cell adhesion molecule 2 isoform X8

      UniProtKB/TrEMBL
      B7Z5K2

    10. XM_054324522.1 → XP_054180497.1  neural cell adhesion molecule 2 isoform X8

      UniProtKB/TrEMBL
      B7Z5K2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15394.2 GenPept UniProtKB/Swiss-Prot:O15394

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