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    PGA1 Pga1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGA1
    Official Full Name
    Pga1p
    Primary source
    SGD:S000005102
    Locus tag
    YNL158W
    See related
    AllianceGenome:SGD:S000005102; FungiDB:YNL158W; VEuPathDB:YNL158W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mannosyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Part of mannosyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGA1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (339612..340208)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Ygp1p Neighboring gene Asi2p Neighboring gene phosphatase regulator Neighboring gene Nsg2p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pga1 is an essential component of Glycosylphosphatidylinositol-mannosyltransferase II of Saccharomyces cerevisiae. Sato K, et al. Mol Biol Cell, 2007 Sep. PMID 17615295, Free PMC Article
    2. Disruption and basic phenotypic analysis of six novel genes from the left arm of chromosome XIV of Saccharomyces cerevisiae. Dueñas E, et al. Yeast, 1999 Jan 15. PMID 10028186
    3. Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Kebaara BW, et al. Nucleic Acids Res, 2009 May. PMID 19270062, Free PMC Article
    4. Members of the RSC chromatin-remodeling complex are required for maintaining proper nuclear envelope structure and pore complex localization. Titus LC, et al. Mol Biol Cell, 2010 Mar 15. PMID 20110349, Free PMC Article
    5. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pga1 is an additional essential component of the yeast Glycosylphosphatidylinositol-mannosyltransferase II.
      Title: Pga1 is an essential component of Glycosylphosphatidylinositol-mannosyltransferase II of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to mannosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannosyltransferase complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of mannosyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 

    General protein information

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    Preferred Names
    Pga1p
    NP_014241.1
    • Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      339612..340208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182996.1 → NP_014241.1  TPA: Pga1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014241.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W125, P53896
      UniProtKB/TrEMBL
      A6ZRS6, B3LP13, B5VQP7, C7GXV8, C8ZG71, G2WLU9, N1NXT3
      Conserved Domains (1) summary
      pfam10333
      Location:14 → 189
      Pga1; GPI-Mannosyltransferase II co-activator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53896.1

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