U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ArfGAP3 ADP-ribosylation factor GTPase activating protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40487, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ArfGAP3provided by FlyBase
    Official Full Name
    ADP-ribosylation factor GTPase activating protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037182
    Locus tag
    Dmel_CG6838
    See related
    AllianceGenome:FB:FBgn0037182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AG2; arfgap1; CG6838; dArfGAP3; Dmel\CG6838
    Summary
    Predicted to enable GTPase activator activity. Involved in compound eye morphogenesis. Located in cytoplasm. Colocalizes with adherens junction. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut; gland; and salivary gland body primordium. Orthologous to several human genes including ARFGAP2 (ADP ribosylation factor GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ArfGAP3 in Genome Data Viewer
    Location:
    79F6-79F6; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22714313..22717577, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22707413..22710677, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46227 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene maelstrom

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Schlacht A, et al. Traffic, 2013 Jun. PMID 23433073, Free PMC Article
    2. ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. Xiong Y, et al. J Neurosci, 2012 Mar 14. PMID 22423108, Free PMC Article
    3. Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Hayward D, et al. Commun Integr Biol, 2014. PMID 25053984, Free PMC Article
    4. Role for a Cindr-Arf6 axis in patterning emerging epithelia. Johnson RI, et al. Mol Biol Cell, 2011 Dec. PMID 21976699, Free PMC Article
    5. Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. Gupta GD, et al. PLoS One, 2009 Aug 26. PMID 19707569, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ADP-ribosylation factor GTPase activating protein 3
    Names
    ArfGAP3-PA
    ArfGAP3-PB
    ArfGAP3-PC
    ArfGAP3-PE
    ArfGAP3-PF
    ArfGAP3-PG
    ArfGAP3-PH
    CG6838-PA
    CG6838-PB
    CG6838-PC
    CG6838-PE
    CG6838-PF
    CG6838-PG
    CG6838-PH

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22714313..22717577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141152.1 → NP_649409.1  ADP-ribosylation factor GTPase activating protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNS2
      Related
      FBpp0078191, FBtr0078539
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    2. NM_001104193.2 → NP_001097663.1  ADP-ribosylation factor GTPase activating protein 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNS2
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    3. NM_001104194.2 → NP_001097664.2  ADP-ribosylation factor GTPase activating protein 3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097664.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNX0
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    4. NM_001275287.1 → NP_001262216.1  ADP-ribosylation factor GTPase activating protein 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG0
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    5. NM_001275288.1 → NP_001262217.1  ADP-ribosylation factor GTPase activating protein 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG88
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    6. NM_001275289.1 → NP_001262218.1  ADP-ribosylation factor GTPase activating protein 3, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIL3
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    7. NM_168955.3 → NP_730735.1  ADP-ribosylation factor GTPase activating protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNS2
      Related
      FBpp0078192
      Conserved Domains (1) summary
      smart00105
      Location:17 → 121
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNX0 A8JNX0
    M9PG88 M9PG88
    M9PGG0 M9PGG0
    M9PIL3 M9PIL3
    Q9VNS2 Q9VNS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous