Hcf Host cell factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hcfprovided by FlyBase
Official Full Name: Host cell factorprovided by FlyBase
Primary source: FLYBASE:FBgn0039904
Locus tag: Dmel_CG1710
See related: AllianceGenome:FB:FBgn0039904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.48; CG1710; dHcf; dHCF; dHcf1; Dmel\CG1710; HCF; Hcf1; HCF1; HCF_DROME
Summary: Enables chromatin binding activity. Involved in chromatin remodeling; positive regulation of DNA-templated transcription; and positive regulation of growth. Located in nucleus. Part of ATAC complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in several structures, including adult head; imaginal disc; ovariole; pole plasm; and primordial germ cell. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Orthologous to human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102B5-102B6; 4-0 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (359938..375554)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (380564..396180)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development.
Title: Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development.
Hcf positively regulates Hippo pathway activity through forming a complex with Trr and controlling H3K4 methylation.
Title: Drosophila Hcf regulates the Hippo signaling pathway via association with the histone H3K4 methyltransferase Trr.
dHCF possesses Enhancer of TrxG and PcG (ETP) properties.
Title: Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators.
down-regulation of dHCF-associated histone acetyltransferase and histone methyltransferase complexes in vivo interferes with the Myc biological activities.
Title: Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth.
Data demonstrate that the Drosophila homologs of mixed-lineage leukemia protein and host cell factor 1, called Trithorax and dHCF, are both cleaved by Drosophila taspase 1.
Title: Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 362145-362207 mobile_element_type = transposon:INE-1{}5366
Loc: 366871-367070 mobile_element_type = transposon:INE-1{}5368
Loc: 369982-370998 mobile_element_type = transposon:1360{}6069
Loc: 373638-373864 mobile_element_type = transposon:INE-1{}5509
Loc: 373907-374053 mobile_element_type = transposon:INE-1{}5362

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of MLL1/2 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of MLL3/4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Set1C/COMPASS complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: host cell factor

Names: CG1710-PA; CG1710-PB; CG1710-PE; CG1710-PF; CG1710-PG; FBgn0039904; Hcf-PA; Hcf-PB; Hcf-PE; Hcf-PF; Hcf-PG; heat cell factor; host cell factor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

359938..375554

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_205873.3 → NP_995595.1 host cell factor, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995595.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V109, H9XVN5, Q8IGU2, Q95S26, Q95ZF3, Q9BKH1, Q9V4C8

Conserved Domains (5) summary

cd00063
Location:1307 → 1338

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:297 → 360

Kelch; KELCH repeat [structural motif]

pfam01344
Location:73 → 110

Kelch_1; Kelch motif

pfam13415
Location:260 → 305

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:175 → 221

Kelch_5; Kelch motif
NM_166756.3 → NP_726566.1 host cell factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V109, H9XVN5, Q8IGU2, Q95S26, Q95ZF3, Q9BKH1, Q9V4C8

Related

FBpp0088194

Conserved Domains (5) summary

cd00063
Location:1307 → 1338

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:297 → 360

Kelch; KELCH repeat [structural motif]

pfam01344
Location:73 → 110

Kelch_1; Kelch motif

pfam13415
Location:260 → 305

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:175 → 221

Kelch_5; Kelch motif
NM_001258491.3 → NP_001245420.1 host cell factor, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245420.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V4C8

Conserved Domains (5) summary

cd00063
Location:1291 → 1322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:297 → 360

Kelch; KELCH repeat [structural motif]

pfam01344
Location:73 → 110

Kelch_1; Kelch motif

pfam13415
Location:260 → 305

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:175 → 221

Kelch_5; Kelch motif
NM_079882.4 → NP_524621.2 host cell factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524621.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V109, H9XVN5, Q8IGU2, Q95S26, Q95ZF3, Q9BKH1, Q9V4C8

Related

FBpp0088195

Conserved Domains (5) summary

cd00063
Location:1307 → 1338

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:297 → 360

Kelch; KELCH repeat [structural motif]

pfam01344
Location:73 → 110

Kelch_1; Kelch motif

pfam13415
Location:260 → 305

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:175 → 221

Kelch_5; Kelch motif
NM_166757.3 → NP_726567.2 host cell factor, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726567.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V4C8

Conserved Domains (5) summary

cd00063
Location:1255 → 1286

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:297 → 360

Kelch; KELCH repeat [structural motif]

pfam01344
Location:73 → 110

Kelch_1; Kelch motif

pfam13415
Location:260 → 305

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:175 → 221

Kelch_5; Kelch motif