Csk C-terminal Src kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cskprovided by FlyBase
Official Full Name: C-terminal Src kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0262081
Locus tag: Dmel_CG42317
See related: AllianceGenome:FB:FBgn0262081
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17309; CG32852; CG42317; csk; CSK; d-Csk; dcsk; dCsk; dCSK; DCsk; Dmel\CG42317; flik; l(3)j1D8; l(3)S017909; Src
Old locus tag: Dmel_CG17309; Dmel_CG32852
Summary: Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including adherens junction maintenance; negative regulation of imaginal disc growth; and positive regulation of hippo signaling. Predicted to be located in cell-cell junction. Predicted to be active in plasma membrane. Is expressed in salivary gland. Orthologous to several human genes including CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 86E13-86E13; 3-51 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11633278..11650706, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7459000..7476428, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-terminal Src kinase (Csk) as a tyrosine kinase is responsible for regulating Gliotactin endocytosis. Increased Csk suppresses the Gliotactin overexpression phenotypes by increasing endocytosis. Loss of Csk causes Gliotactin to spread away from the Tricellular junctions.
Title: C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src.
Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII.
Title: C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
dCsk is another upstream member of the network of genes that interact to regulate Wts and its effector Yki in the Hippo signaling pathway
Title: Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway.
A functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism.
Title: Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells.
Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
Title: Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
Title: Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.
Results demonstrate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging of germline cysts by overlying somatic follicle cells during egg chamber formation.
Title: Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells.
C-terminal Src kinase (CSK) in Drosophila was identified in a genetic modifier screen for genes that interact with the lats tumor suppressor gene. CSK regulates cell proliferation and organ size.
Title: A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-terminal Src kinase

Names: C-Src kinase; C-terminal-Src kinase; CG42317-PF; CG42317-PG; CG42317-PH; CG42317-PI; CG42317-PJ; CG42317-PK; CG42317-PL; Csk-PF; Csk-PG; Csk-PH; Csk-PI; Csk-PJ; Csk-PK; Csk-PL; drosophila C-terminal Src kinase; flik; lethal (3) S017909; lethal (3) j1D8

NP_001262476.1

EC 2.7.10.2

NP_650097.2

EC 2.7.10.2

NP_731607.1

EC 2.7.10.2

NP_731608.1

EC 2.7.10.2

NP_731609.1

EC 2.7.10.2

NP_731611.2

EC 2.7.10.2

NP_788638.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11633278..11650706 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169414.2 → NP_731607.1 C-terminal Src kinase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731607.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP28, Q7KSQ2

Related

FBpp0289774

Conserved Domains (3) summary

cd09937
Location:351 → 448

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:471 → 715

STYKc; Protein kinase; unclassified specificity

cd05039
Location:464 → 718

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
NM_169418.3 → NP_731611.2 C-terminal Src kinase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731611.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8INJ8

Conserved Domains (3) summary

cd09937
Location:680 → 777

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:800 → 1044

STYKc; Protein kinase; unclassified specificity

cd05039
Location:793 → 1047

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
NM_141840.1 → NP_650097.2 C-terminal Src kinase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650097.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP28, Q9VGK8, Q9VGK9

Related

FBpp0289773, FBtr0300546

Conserved Domains (3) summary

cd09937
Location:433 → 530

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:553 → 797

STYKc; Protein kinase; unclassified specificity

cd05039
Location:546 → 800

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
NM_001275547.1 → NP_001262476.1 C-terminal Src kinase, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262476.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8INJ8

Conserved Domains (3) summary

cd09937
Location:680 → 777

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:800 → 1044

STYKc; Protein kinase; unclassified specificity

cd05039
Location:793 → 1047

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
NM_176461.1 → NP_788638.1 C-terminal Src kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788638.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP28, Q7KSQ2

Related

FBpp0289006, FBtr0299728

Conserved Domains (3) summary

cd09937
Location:351 → 448

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:471 → 715

STYKc; Protein kinase; unclassified specificity

cd05039
Location:464 → 718

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
NM_169415.2 → NP_731608.1 C-terminal Src kinase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731608.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP28, Q7KSQ2

Related

FBpp0289775, FBtr0300548

Conserved Domains (3) summary

cd09937
Location:351 → 448

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:471 → 715

STYKc; Protein kinase; unclassified specificity

cd05039
Location:464 → 718

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
NM_169416.2 → NP_731609.1 C-terminal Src kinase, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731609.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP28, Q7KSQ2

Related

FBpp0289776, FBtr0300549

Conserved Domains (3) summary

cd09937
Location:351 → 448

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

smart00221
Location:471 → 715

STYKc; Protein kinase; unclassified specificity

cd05039
Location:464 → 718

PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases