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    CG8539 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8539provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035791
    Locus tag
    Dmel_CG8539
    See related
    AllianceGenome:FB:FBgn0035791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8539
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and photoreceptor neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8539 in Genome Data Viewer
    Location:
    66A2-66A2; 3-21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7497211..7498831, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7490311..7491931, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 316a1 Neighboring gene Cytochrome P450 4d8 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45896 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila. Shukla V, et al. G3 (Bethesda), 2018 May 31. PMID 29669801, Free PMC Article
    2. Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex. Arbeitman MN, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172187, Free PMC Article
    3. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article
    4. Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Landry CR, et al. Genetics, 2005 Dec. PMID 16143608, Free PMC Article
    5. Evolutionary changes in cis and trans gene regulation. Wittkopp PJ, et al. Nature, 2004 Jul 1. PMID 15229602

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8539-PA
    CG8539-PB
    NP_001261520.1
    NP_648130.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7497211..7498831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274591.1 → NP_001261520.1  uncharacterized protein Dmel_CG8539, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261520.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZR4, Q9VS80
      Conserved Domains (1) summary
      cd03860
      Location:38 → 335
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like

    2. NM_139873.3 → NP_648130.2  uncharacterized protein Dmel_CG8539, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648130.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZR4, Q9VS80
      Related
      FBpp0076542
      Conserved Domains (1) summary
      cd03860
      Location:38 → 335
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZR4 Q8SZR4
    Q9VS80 Q9VS80

    Gene LinkOut

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