AP-1-2beta Adaptor Protein complex 1/2, beta subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AP-1-2betaprovided by FlyBase
Official Full Name: Adaptor Protein complex 1/2, beta subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0010380
Locus tag: Dmel_CG12532
See related: AllianceGenome:FB:FBgn0010380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AP-1; AP-1-2-beta; AP-1/2beta; AP-1beta; AP-1beta1; AP-2beta; AP-beta1; AP1beta1; AP2beta; AP2beta2; apl1; apl2; BAD1; bap; Bap; BAP; Beta-adaptin; beta1/2; beta2-ada; cg12532; CG12532; Dmel\CG12532
Summary: Predicted to enable clathrin adaptor activity. Involved in compound eye development and positive regulation of autophagy. Located in several cellular components, including clathrin-coated pit; clathrin-coated vesicle; and trans-Golgi network. Part of AP-type membrane coat adaptor complex. Is expressed in adult head and adult heart. Orthologous to several human genes including AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19731004..19734581)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19625037..19628614)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

AP-2beta up-regulates the transcription of the CRYAB gene through stabilizing p53.
Title: AP-2β enhances p53-mediated transcription of the αB-crystallin gene through stabilizing p53.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IC Inferred by Curator more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IC Inferred by Curator more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of AP-type membrane coat adaptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of membrane coat	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

Names: AP-1-2beta-PA; CG12532-PA; adaptin AP1 beta; beta adaptin; beta adaptin drosophila 1; beta-adaptin; beta2-adaptin; clathrin AP-2 complex

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