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    pea peanuts [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    peaprovided by FlyBase
    Official Full Name
    peanutsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086895
    Locus tag
    Dmel_CG8241
    See related
    AllianceGenome:FB:FBgn0086895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8241; CG8241; Dmel\CG8241; prp22; Prp22
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Involved in chromatin organization and oogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Orthologous to human DHX8 (DEAH-box helicase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pea in Genome Data Viewer
    Location:
    50E1-50E1; 2-69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14153153..14157106)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10040658..10044611)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-989 stem loop Neighboring gene Reduction in Cnn dots 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cysteinyl-tRNA synthetase, mitochondrial Neighboring gene O-fucosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The septins: roles in cytokinesis and other processes. Longtine MS, et al. Curr Opin Cell Biol, 1996 Feb. PMID 8791410
    2. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells. Klusza S, et al. PLoS One, 2013. PMID 24244416, Free PMC Article
    3. Flanking duplications and deletions associated with P-induced male recombination in Drosophila. Preston CR, et al. Genetics, 1996 Dec. PMID 8978050, Free PMC Article
    4. RNA-Seq Analysis of Differential Splice Junction Usage and Intron Retentions by DEXSeq. Li Y, et al. PLoS One, 2015. PMID 26327458, Free PMC Article
    5. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells.
      Title: Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peanuts
    Names
    CG8241-PA
    pea-PA
    NP_610928.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14153153..14157106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137084.3 → NP_610928.1  peanuts [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9L3, Q8MSQ6
      Related
      FBpp0086647
      Conserved Domains (2) summary
      COG1643
      Location:573 → 1221
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd05684
      Location:285 → 363
      S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9L3.1 A1Z9L3

    Gene LinkOut

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