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    Orct2 Organic cation transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orct2provided by FlyBase
    Official Full Name
    Organic cation transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0086365
    Locus tag
    Dmel_CG13610
    See related
    AllianceGenome:FB:FBgn0086365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cald; CG13610; Dmel\CG13610; EP(3)1072; EP1072; orct2
    Summary
    Predicted to enable organic cation transmembrane transporter activity. Involved in positive regulation of cell growth. Predicted to be located in membrane. Is expressed in several structures, including adult head; antennal primordium; central brain primordium; embryonic proventriculus; and head epidermis primordium. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Orct2 in Genome Data Viewer
    Location:
    95F8-95F8; 3-84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24273029..24275728)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20098751..20101450)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phenylalanyl-tRNA synthetase, beta-subunit Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1 Neighboring gene Organic cation transporter Neighboring gene sheepish

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier. Li F, et al. Elife, 2023 May 4. PMID 37140181, Free PMC Article
    2. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies. Gai Y, et al. Neuron, 2016 May 4. PMID 27146270, Free PMC Article
    3. calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Herranz H, et al. Development, 2006 Jul. PMID 16774996
    4. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
    5. Severe Fertility Effects of sheepish Sperm Caused by Failure To Enter Female Sperm Storage Organs in Drosophila melanogaster. Tomaru M, et al. G3 (Bethesda), 2018 Jan 4. PMID 29158336, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identify calderon, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the insulin receptor pathway
      Title: calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    organic cation transporter 2
    Names
    CG13610-PA
    CG13610-PB
    EP1072
    Orct2-PA
    Orct2-PB
    calderon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24273029..24275728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275978.2 → NP_001262907.1  organic cation transporter 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R48, Q9VCA3
      UniProtKB/TrEMBL
      A0A0B4KHD4, R9QRG4
      Conserved Domains (2) summary
      cd06174
      Location:127 → 503
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 520
      2A0119; cation transport protein

    2. NM_142981.3 → NP_651238.2  organic cation transporter 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651238.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R48, Q9VCA3
      UniProtKB/TrEMBL
      A0A0B4KHD4, R9QRG4
      Related
      FBpp0083982
      Conserved Domains (2) summary
      cd06174
      Location:127 → 503
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 520
      2A0119; cation transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHD4 A0A0B4KHD4
    Q95R48.2 Q95R48

    Gene LinkOut

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