eIF3h eukaryotic translation initiation factor 3 subunit h [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF3hprovided by FlyBase
Official Full Name: eukaryotic translation initiation factor 3 subunit hprovided by FlyBase
Primary source: FLYBASE:FBgn0022023
Locus tag: Dmel_CG9124
See related: AllianceGenome:FB:FBgn0022023
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM14618; CG9124; Dmel\CG9124; eIF-3; eIF-3p40; eIf3-p44; eIF3-S3; EIF3H; eIF3p40; l(2)k09003; Q9U9Q4
Summary: Predicted to enable metal-dependent deubiquitinase activity. Predicted to contribute to translation initiation factor activity. Involved in positive regulation of Notch signaling pathway. Predicted to be located in cytosol. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25C3-25C3; 2-15 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5051193..5053094, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5051193..5053094, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of eukaryotic 43S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit h

Names: CG9124-PA; CG9124-PB; eIF3h-PA; eIF3h-PB; eukaryotic initiation factor 3 p40 subunit

NP_524834.2

EC 3.4.-.-

NP_995631.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5051193..5053094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080095.4 → NP_524834.2 eukaryotic translation initiation factor 3 subunit h, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524834.2

Status: REVIEWED

UniProtKB/Swiss-Prot

C0PTU9, Q7KLX2, Q9U9Q4, Q9VMU9

Related

FBpp0078667

Conserved Domains (1) summary

cd08065
Location:20 → 281

MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
NM_205909.3 → NP_995631.1 eukaryotic translation initiation factor 3 subunit h, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0PTU9, Q7KLX2, Q9U9Q4, Q9VMU9

Conserved Domains (1) summary

cd08065
Location:20 → 281

MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h