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    ZAP3 ZAP3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZAP3provided by FlyBase
    Official Full Name
    ZAP3provided by FlyBase
    Primary source
    FLYBASE:FBgn0052685
    Locus tag
    Dmel_CG32685
    See related
    AllianceGenome:FB:FBgn0052685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12646; CG12647; CG2971; CG32685; Dmel\CG32685; Zap3
    Summary
    Enables protein phosphatase 1 binding activity. Predicted to be involved in regulation of telomere maintenance. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; head epidermis primordium; and mesoderm. Orthologous to human YLPM1 (YLP motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ZAP3 in Genome Data Viewer
    Location:
    9B1-9B1; 1-31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10071858..10082492, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9965891..9976525, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45602 Neighboring gene Gustatory receptor 9a Neighboring gene uncharacterized protein Neighboring gene NAD(P)HX epimerase Neighboring gene RhoU Neighboring gene antisense RNA:CR44894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes. Demakova OV, et al. Chromosoma, 2020 Mar. PMID 31820086
    2. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873
    3. Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation. Stewart RK, et al. Nat Commun, 2024 Jun 20. PMID 38902233, Free PMC Article
    4. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article
    5. Systematic analysis of YFP traps reveals common mRNA/protein discordance in neural tissues. Titlow JS, et al. J Cell Biol, 2023 Jun 5. PMID 37145332, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ZAP3
    Names
    CG32685-PC
    CG32685-PD
    CG32685-PE
    CG32685-PF
    ZAP3-PC
    ZAP3-PD
    ZAP3-PE
    ZAP3-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10071858..10082492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167218.2 → NP_727393.1  ZAP3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2Y5
      Related
      FBpp0071418
      Conserved Domains (1) summary
      pfam13238
      Location:1559 → 1694
      AAA_18; AAA domain

    2. NM_001258678.2 → NP_001245607.1  ZAP3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGY4
      Conserved Domains (1) summary
      pfam13238
      Location:1560 → 1695
      AAA_18; AAA domain

    3. NM_001258677.2 → NP_001245606.1  ZAP3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQW1, M9NF08
      Conserved Domains (1) summary
      PTZ00395
      Location:247 → 483
      PTZ00395; Sec24-related protein; Provisional

    4. NM_001258679.2 → NP_001245608.1  ZAP3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C574, M9NDT5
      Conserved Domains (1) summary
      PTZ00395
      Location:247 → 483
      PTZ00395; Sec24-related protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDT5 M9NDT5
    M9NF08 M9NF08
    M9NGY4 M9NGY4
    Q8SWX1 Q8SWX1
    Q9W2Y5 Q9W2Y5

    Gene LinkOut

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