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    Amph Amphiphysin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amphprovided by FlyBase
    Official Full Name
    Amphiphysinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027356
    Locus tag
    Dmel_CG8604
    See related
    AllianceGenome:FB:FBgn0027356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Amp; amph; Bin1; CG8604; dAmp; Damp; DAMP; damph; dAmph; Dmel\CG8604
    Summary
    Predicted to enable phospholipid binding activity. Involved in protein localization; regulation of muscle contraction; and rhabdomere membrane biogenesis. Located in cleavage furrow and synapse. Is expressed in several structures, including epithelial cell; epithelium; garland cell; gut section; and larval somatic muscle cell. Used to study centronuclear myopathy 2. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to several human genes including BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Amph in Genome Data Viewer
    Location:
    49B7-49B8; 2-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12593604..12612068)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8481109..8499573)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chloride channel-b Neighboring gene Sin3A Neighboring gene long non-coding RNA:CR30055 Neighboring gene long non-coding RNA:CR45279 Neighboring gene long non-coding RNA:CR43909 Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit q Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Peter BJ, et al. Science, 2004 Jan 23. PMID 14645856
    2. Membrane-bending mechanism of amphiphysin N-BAR domains. Arkhipov A, et al. Biophys J, 2009 Nov 18. PMID 19917226, Free PMC Article
    3. Four-scale description of membrane sculpting by BAR domains. Arkhipov A, et al. Biophys J, 2008 Sep 15. PMID 18515394, Free PMC Article
    4. Osmotically-induced tension and the binding of N-BAR protein to lipid vesicles. Hutchison JB, et al. Soft Matter, 2016 Feb 28. PMID 26822233
    5. Membrane curvature: how BAR domains bend bilayers. Zimmerberg J, et al. Curr Biol, 2004 Mar 23. PMID 15043839

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Co-immunoprecipitation analysis supports association between Ma2/d and Amph, and indirectly with Msp300. Ma2/d, in association with Msp300 and Amph, mediates interactions between the SR and the nuclear membrane.
      Title: Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum.
    2. Our study indicates that the H0 helix and the BAR tip are necessary for efficient and organized self-assembly of amphiphysin/N-BAR
      Title: Structural insights into the cooperative remodeling of membranes by amphiphysin/BIN1.
    3. Cleavage furrow tips tubule formation requires the BAR domain of amphiphysin.
      Title: The BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos.
    4. This study challenges the notion that synaptic Amphiphysin is involved exclusively in endocytosis and suggests a novel role for this protein in postsynaptic exocytosis
      Title: Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling.
    5. the structure of the Drosophila amphiphysin BAR domain was solved; the universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module
      Title: BAR domains as sensors of membrane curvature: the amphiphysin BAR structure.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in synaptic vesicle endocytosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amphiphysin
    Names
    Amph-PA
    Amph-PB
    Amph-PC
    CG8604-PA
    CG8604-PB
    CG8604-PC
    amphiphysin/BIN1
    dAmphiphysin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12593604..12612068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078993.3 → NP_523717.1  amphiphysin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KLE5
      Related
      FBpp0086941
      Conserved Domains (2) summary
      cd07588
      Location:26 → 238
      BAR_Amphiphysin; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysins
      cd11790
      Location:539 → 602
      SH3_Amphiphysin; Src Homology 3 domain of Amphiphysin and related domains

    2. NM_001273990.1 → NP_001260919.1  amphiphysin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEW6
      Conserved Domains (2) summary
      cd07588
      Location:26 → 238
      BAR_Amphiphysin; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysins
      cd11790
      Location:439 → 502
      SH3_Amphiphysin; Src Homology 3 domain of Amphiphysin and related domains

    3. NM_001273991.1 → NP_001260920.1  amphiphysin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFR7
      Conserved Domains (2) summary
      cd07588
      Location:26 → 238
      BAR_Amphiphysin; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysins
      cd11790
      Location:303 → 373
      SH3_Amphiphysin; Src Homology 3 domain of Amphiphysin and related domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEW6 A0A0B4KEW6
    A0A0B4KFR7 A0A0B4KFR7
    Q7KLE5 Q7KLE5

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