U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    otk2 off-track2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36284, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    otk2provided by FlyBase
    Official Full Name
    off-track2provided by FlyBase
    Primary source
    FLYBASE:FBgn0267728
    Locus tag
    Dmel_CG8964
    See related
    AllianceGenome:FB:FBgn0267728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8964; CT25760; Dmel\CG8964; l(2)SH1639; l(2)SH2 1639; otK2
    Summary
    Enables Wnt-protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in imaginal disc-derived female genitalia morphogenesis; imaginal disc-derived male genitalia morphogenesis; and internal genitalia morphogenesis. Predicted to be located in membrane. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including adult fat body; adult head; embryonic/larval gut; imaginal disc; and larval brain. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See otk2 in Genome Data Viewer
    Location:
    48D7-48D7; 2-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12023146..12025272, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7910651..7912777, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45319 Neighboring gene long non-coding RNA:CR45318 Neighboring gene off-track Neighboring gene long non-coding RNA:CR44306 Neighboring gene Metallophosphoesterase Neighboring gene precocious dissociation of sisters 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning. Tan QH, et al. Cells, 2024 Feb 20. PMID 38474329, Free PMC Article
    2. The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. Linnemannstöns K, et al. PLoS Genet, 2014 Jul. PMID 25010066, Free PMC Article
    3. Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands. Ripp C, et al. Biol Open, 2018 Nov 2. PMID 30341100, Free PMC Article
    4. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article
    5. Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury. Hu DJ, et al. Nat Commun, 2021 Dec 9. PMID 34887411, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived female genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in internal genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    off-track2
    Names
    CG8964-PA
    lethal (2) SH1639
    otk2-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12023146..12025272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138561.3 → NP_612571.1  off-track2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JXW8
      Related
      FBpp0087134
      Conserved Domains (3) summary
      smart00408
      Location:258 → 323
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:250 → 331
      IG_like; Immunoglobulin like
      pfam07679
      Location:155 → 238
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXW8 Q7JXW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools