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    swa swallow [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swaprovided by FlyBase
    Official Full Name
    swallowprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003655
    Locus tag
    Dmel_CG3429
    See related
    AllianceGenome:FB:FBgn0003655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.70; CG3429; Dmel\CG3429; fs(1)1497; fs(1)1502; fs(1)M11-999; fs(1)M13C82; fs(1)m44; fs(1)M44; Swa; sww
    Summary
    Predicted to enable mRNA binding activity. Involved in actin filament organization; pole plasm mRNA localization; and regulation of pole plasm oskar mRNA localization. Is expressed in egg chamber; nurse cell; oocyte; organism; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See swa in Genome Data Viewer
    Location:
    5F4-5F4; 1-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6363418..6365708, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6257451..6259741, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene knockdown Neighboring gene swallow pseudogene Neighboring gene Mitochondrial assembly regulatory factor Neighboring gene long non-coding RNA:CR44816 Neighboring gene Protein phosphatase V

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of swallow-Green Fluorescent Protein in Drosophila oogenesis and implications for the role of swallow in RNA localization. Stephenson EC. Genesis, 2004 Aug. PMID 15287001
    2. Structural characterization of the self-association domain of swallow. Loening NM, et al. Protein Sci, 2021 May. PMID 33641207, Free PMC Article
    3. Isolation of Drosophila clones encoding maternally restricted RNAs. Stephenson EC, et al. Dev Biol, 1987 Nov. PMID 2444476
    4. Sequence of swallow, a gene required for the localization of bicoid message in Drosophila eggs. Chao YC, et al. Dev Genet, 1991. PMID 1806330
    5. Structural features of LC8-induced self-association of swallow. Kidane AI, et al. Biochemistry, 2013 Sep 3. PMID 23914803, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization of the self-association domain of swallow.
      Title: Structural characterization of the self-association domain of swallow.
    2. Swa is crucial for the organization of actin networks that lead to the formation of a specialized microtubule population, while Ovhts-RC acts to modulate spatially restricted actin filament growth at the oocyte cortex.
      Title: Distinct roles for hu li tai shao and swallow in cytoskeletal organization during Drosophila oogenesis.
    3. Results exclude a role for Swallow in linking bicoid mRNA to the dynein motor.
      Title: Distinguishing direct from indirect roles for bicoid mRNA localization factors.
    4. binding of LC8 to Swallow serves another function, possibly that of a dimerization engine, which is independent of its role in dynein
      Title: Structure and dynamics of LC8 complexes with KXTQT-motif peptides: swallow and dynein intermediate chain compete for a common site.
    5. the cytoskeleton in swa mutant oocytes and embryos
      Title: Oocyte and embryonic cytoskeletal defects caused by mutations in the Drosophila swallow gene.
    6. Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod, and RNA binding proteins.
      Title: Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod, and RNA binding proteins.
    7. Molecular characterization of alleles of swallow that may affect swallow function.
      Title: Identification of hypomorphic and null alleles of swallow via molecular and phenotypic analyses.
    8. The weak coiled-coil domain of Drosophila swallow binds tightly to LC8 and becomes significantly more stable in vitro, less susceptible to proteolysis, and more capable of binding other macromolecules in the dynein complex.
      Title: Dynein light chain LC8 promotes assembly of the coiled-coil domain of swallow protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein complex binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterior/posterior axis specification, embryo IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in bicoid mRNA localization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in bicoid mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pole plasm oskar mRNA localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    swallow
    Names
    CG3429-PA
    swa-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6363418..6365708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078505.4 → NP_511060.2  swallow [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511060.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40688, Q9W400
      Related
      FBpp0070884
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40688.1 P40688

    Gene LinkOut

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