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    Est-P Esterase P [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Est-Pprovided by FlyBase
    Official Full Name
    Esterase Pprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000594
    Locus tag
    Dmel_CG17148
    See related
    AllianceGenome:FB:FBgn0000594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17148; Dmel\CG17148; Est-5; EST-5; Est-7; est-P; Est7; EST7; EstP; ESTP; psiEst-6; PsiEst-6; yEst-6; yEst6
    Summary
    Enables carboxylesterase activity. Is expressed in organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Est-P in Genome Data Viewer
    Location:
    69A1-69A1; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12190733..12192528)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12183833..12185628)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myo-inositol oxygenase Neighboring gene Esterase 6 Neighboring gene thoc6 Neighboring gene long non-coding RNA:CR45746 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Associations between restriction site polymorphism and enzyme activity variation for esterase 6 in Drosophila melanogaster. Game AY, et al. Genetics, 1990 Dec. PMID 1981760, Free PMC Article
    2. Characterization of the EstP protein in Drosophila melanogaster and its conservation in drosophilids. Dumancic MM, et al. Biochem Genet, 1997 Aug. PMID 9435945
    3. Molecular population genetics of the beta-esterase gene cluster of Drosophila melanogaster. Balakirev ES, et al. J Genet, 2003 Dec. PMID 15133190
    4. The beta-esterase gene cluster of drosophila melanogaster: is psiEst-6 a pseudogene, a functional gene, or both? Balakirev ES, et al. Genetica, 2004 Jun. PMID 15330116
    5. Positive and negative selection in the beta-esterase gene cluster of the Drosophila melanogaster subgroup. Balakirev ES, et al. J Mol Evol, 2006 Apr. PMID 16547641

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 

    General protein information

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    Preferred Names
    esterase P
    Names
    CG17148-PA
    Est-P-PA
    NP_788501.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12190733..12192528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176323.2 → NP_788501.1  esterase P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18167, Q32KD6, Q9VTV0
      Related
      FBpp0075736
      Conserved Domains (2) summary
      COG0657
      Location:107 → 240
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cd00312
      Location:26 → 537
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18167.2 P18167

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