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    FER FER tyrosine kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FERprovided by FlyBase
    Official Full Name
    FER tyrosine kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000723
    Locus tag
    Dmel_CG8874
    See related
    AllianceGenome:FB:FBgn0000723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8874; dfer; dFer; Dfer; DFer; DFER; dfps; Dfps; dfps 85D; dfps85D; Dm FPS; Dmel\CG8874; DmHD-179; fer; Fer; fps; FPS; fps85D; Fps85D; FpS95D; HD-179
    Summary
    Predicted to enable phospholipid binding activity and protein tyrosine kinase activity. Involved in actin filament bundle assembly; axon guidance; and dorsal closure. Is extrinsic component of cytoplasmic side of plasma membrane. Colocalizes with adherens junction. Is expressed in adult brain; adult head; and eye. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FER in Genome Data Viewer
    Location:
    85D13-85D15; 3-48 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9367603..9394546, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5193325..5220268, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene doctor no Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serine racemase Neighboring gene antisense RNA:CR46145 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 85f

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DFer gene of Drosophila melanogaster encodes two membrane-associated proteins that can both transform vertebrate cells. Paulson R, et al. Oncogene, 1997 Feb 13. PMID 9038371
    2. A gene related to the proto-oncogene fps/fes is expressed at diverse times during the life cycle of Drosophila melanogaster. Katzen AL, et al. Mol Cell Biol, 1991 Jan. PMID 1898762, Free PMC Article
    3. Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Juang JL, et al. Oncogene, 1999 Sep 16. PMID 10498863
    4. Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins. Gibson TJ, et al. Trends Genet, 1998 Feb. PMID 9520595
    5. enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Gertler FB, et al. Genes Dev, 1995 Mar 1. PMID 7535279

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal closure, amnioserosa morphology change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, elongation of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FER tyrosine kinase
    Names
    CG8874-PA
    CG8874-PB
    CG8874-PC
    CG8874-PD
    CG8874-PE
    CG8874-PF
    CG8874-PG
    FER ortholog
    FER-PA
    FER-PB
    FER-PC
    FER-PD
    FER-PE
    FER-PF
    FER-PG
    Fps oncogene analog
    NP_001262411.1
    NP_001262412.1
    NP_001368998.1
    NP_524288.3
    NP_731341.1
    NP_731342.1
    NP_731343.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9367603..9394546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169274.2 → NP_731341.1  FER tyrosine kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18106
      Related
      FBpp0081529
      Conserved Domains (4) summary
      cd07657
      Location:7 → 243
      F-BAR_Fes_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases
      smart00219
      Location:542 → 790
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:432 → 518
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:546 → 794
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases

    2. NM_001275482.1 → NP_001262411.1  FER tyrosine kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGK6
      Conserved Domains (4) summary
      cd07657
      Location:7 → 243
      F-BAR_Fes_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases
      smart00219
      Location:609 → 857
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:499 → 585
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:613 → 861
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases

    3. NM_079564.4 → NP_524288.3  FER tyrosine kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524288.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18106, Q27576, Q86P62, Q8INP1, Q8INP2, Q9TYI1, Q9VHE7, Q9VHE8
      Related
      FBpp0081530
      Conserved Domains (4) summary
      cd07657
      Location:7 → 243
      F-BAR_Fes_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases
      smart00219
      Location:1063 → 1311
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:953 → 1039
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:1067 → 1315
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases

    4. NM_001275483.1 → NP_001262412.1  FER tyrosine kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFK7
      Conserved Domains (4) summary
      cd07657
      Location:7 → 243
      F-BAR_Fes_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases
      smart00219
      Location:610 → 858
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:500 → 586
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:614 → 862
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases

    5. NM_169275.2 → NP_731342.1  FER tyrosine kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18106
      Related
      FBpp0081531
      Conserved Domains (3) summary
      smart00219
      Location:213 → 461
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:103 → 189
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:217 → 465
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases

    6. NM_169276.2 → NP_731343.1  FER tyrosine kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18106
      Related
      FBpp0081532
      Conserved Domains (3) summary
      smart00219
      Location:131 → 379
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:21 → 107
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:135 → 383
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases

    7. NM_001382200.1 → NP_001368998.1  FER tyrosine kinase, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEN6
      Conserved Domains (2) summary
      cd10361
      Location:49 → 135
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05041
      Location:163 → 411
      PTKc_Fes_like; Catalytic domain of Fes-like Protein Tyrosine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFK7 A0A0B4KFK7
    A0A0B4KGK6 A0A0B4KGK6
    A0A6H2EEN6 A0A6H2EEN6
    P18106.3 P18106
    Q8WRX4 Q8WRX4

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