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    Yp1 Yolk protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yp1provided by FlyBase
    Official Full Name
    Yolk protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004045
    Locus tag
    Dmel_CG2985
    See related
    AllianceGenome:FB:FBgn0004045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2985; Dmel\CG2985; DmYP1; fs(1)1163; fs(1)A1163; VG1; VIT1Dm; yp; YP; yp-1; YP-1; yp1; YP1; YPI; YP[[1]]
    Summary
    Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adult fat body; adult head; antennal primordium; embryonic antennal sense organ; and sperm storage organ. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Yp1 in Genome Data Viewer
    Location:
    9A5-9A5; 1-30 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10053811..10055498)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9947844..9949531)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Chitinase 6 Neighboring gene antisense RNA:CR45185 Neighboring gene antisense RNA:CR45601 Neighboring gene Yolk protein 2 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 9a Neighboring gene long non-coding RNA:CR45602

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries. Bownes M, et al. Insect Mol Biol, 2002 Oct. PMID 12230547
    2. Insect population control using female specific pro-drug activation. Markaki M, et al. Insect Biochem Mol Biol, 2004 Feb. PMID 14871609
    3. Developmental regulation of yolk protein gene expression in Anastrepha suspensa. Handler AM. Arch Insect Biochem Physiol, 1997. PMID 9243791
    4. Effects of Food and Temperature on Drosophila melanogaster Reproductive Dormancy as Revealed by Quantification of a GFP-Tagged Yolk Protein in the Ovary. Hara Y, et al. Front Physiol, 2021. PMID 35046840, Free PMC Article
    5. A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program. Heinrich JC, et al. Proc Natl Acad Sci U S A, 2000 Jul 18. PMID 10890889, Free PMC Article

    See all (246) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of all YP1, YP2 and YP3 genes was shown to be a unique feature of testis tissues.
      Title: Yolk proteins in the male reproductive system of the fruit fly Drosophila melanogaster: spatial and temporal patterns of expression.
    2. Yp (Yolk protein) expression is significantly negatively correlated with longevity, an important life history trait, for both males and females.
      Title: Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.
    3. cloned the Drosophila yp1 gene into an E. coli expression vector and showed that the yolk protein produced by E. coli is taken up into ovaries of both Drosophila melanogaster and the malaria mosquito Anopheles gambiae
      Title: Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables lipase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sex differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    yolk protein 1
    Names
    CG2985-PA
    CG2985-PB
    Yok protein 1
    Yp1-PA
    Yp1-PB
    vitellogenin
    yolk protein
    yolk protein I
    yolk-protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10053811..10055498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298142.1 → NP_001285071.1  yolk protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285071.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02843, Q8SXV7, Q9W2Y9
      UniProtKB/TrEMBL
      Q29QE3, X2JD55
      Conserved Domains (1) summary
      cl21494
      Location:183 → 406
      Abhydrolase; alpha/beta hydrolases

    2. NM_078548.3 → NP_511103.1  yolk protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02843, Q8SXV7, Q9W2Y9
      UniProtKB/TrEMBL
      Q29QE3, X2JD55
      Related
      FBpp0071354
      Conserved Domains (1) summary
      cl21494
      Location:183 → 406
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02843.1 P02843
    X2JD55 X2JD55

    Gene LinkOut

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