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    Klp54D Kinesin-like protein at 54D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klp54Dprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 54Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263076
    Locus tag
    Dmel_CG43323
    See related
    AllianceGenome:FB:FBgn0263076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15844; CG43323; Dmel\CG43323; DmKlp54D; KIF 12; KIF12; Klp1; KLP1; KLP54D
    Old locus tag
    Dmel_CG15844
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in adult brain cell body rind and adult gnathal ganglion. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Klp54D in Genome Data Viewer
    Location:
    54C5-54C8; 2-83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17557031..17563406)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13444536..13450790)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L18A Neighboring gene Misexpression suppressor of ras 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nucleostemin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes. Radford SJ, et al. Genetics, 2017 Feb. PMID 27932541, Free PMC Article
    2. Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules. Feng C, et al. J Cell Sci, 2021 Jun 1. PMID 34096607, Free PMC Article
    3. Identification and partial characterization of six members of the kinesin superfamily in Drosophila. Stewart RJ, et al. Proc Natl Acad Sci U S A, 1991 Oct 1. PMID 1924306, Free PMC Article
    4. An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster. Dalby B, et al. Genetics, 1995 Feb. PMID 7713430, Free PMC Article
    5. Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells. Deng Q, et al. EMBO J, 2021 Oct 1. PMID 34368973, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein at 54D
    Names
    CG43323-PA
    CG43323-PB
    CG43323-PC
    CG43323-PD
    CG43323-PE
    Kinesin-like protein 54D
    Kinesin4A
    Klp54D-PA
    Klp54D-PB
    Klp54D-PC
    Klp54D-PD
    Klp54D-PE
    NP_001303355.1
    • non-AUG (GUG) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17557031..17563406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316425.1 → NP_001303354.1  Kinesin-like protein at 54D, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUN4
      Conserved Domains (2) summary
      smart00129
      Location:133 → 487
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:133 → 479
      KISc; Kinesin motor domain

    2. NM_001316426.1 → NP_001303355.1  Kinesin-like protein at 54D, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUN8
      Conserved Domains (2) summary
      smart00129
      Location:166 → 520
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:166 → 512
      KISc; Kinesin motor domain

    3. NM_080144.3 → NP_524883.2  Kinesin-like protein at 54D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524883.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAV4
      Conserved Domains (2) summary
      smart00129
      Location:133 → 487
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:133 → 479
      KISc; Kinesin motor domain

    4. NM_001259469.2 → NP_001246398.1  Kinesin-like protein at 54D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG1
      Conserved Domains (2) summary
      smart00129
      Location:133 → 487
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:133 → 479
      KISc; Kinesin motor domain

    5. NM_001299610.1 → NP_001286539.1  Kinesin-like protein at 54D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFQ8
      Conserved Domains (2) summary
      smart00129
      Location:133 → 487
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:133 → 479
      KISc; Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFQ8 A0A0B4LFQ8
    A0A126GUN4 A0A126GUN4
    A0A126GUN8 A0A126GUN8
    A1ZAV4 A1ZAV4
    D2NUG1 D2NUG1
    Q00082 Q00082

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