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    fzo fuzzy onions [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fzoprovided by FlyBase
    Official Full Name
    fuzzy onionsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011596
    Locus tag
    Dmel_CG4568
    See related
    AllianceGenome:FB:FBgn0011596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0125274.1; anon-WO0125274.25; anon-WO0125274.26; CG4568; Dmel\CG4568; Fzo; mfn1; MFN1
    Summary
    Predicted to enable GTPase activity. Involved in Nebenkern assembly; mitochondrion organization; and positive regulation of mitochondrial fusion. Located in mitochondrial envelope. Is expressed in several structures, including Nebenkern; embryonic hypopharynx; hypopharynx proper primordium; male germline cell; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fzo in Genome Data Viewer
    Location:
    94E6-94E6; 3-78 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23201644..23204034, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19027366..19029756, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Inwardly rectifying potassium channel 1 Neighboring gene uncharacterized protein Neighboring gene cap-n-collar Neighboring gene uncharacterized protein Neighboring gene Rad60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic mitochondria. Yaffe MP. Nat Cell Biol, 1999 Oct. PMID 10559975
    2. Mitochondrial division: New partners in membrane pinching. Yoon Y, et al. Curr Biol, 2001 Jan 23. PMID 11231145
    3. Mitochondrial dynamics during spermatogenesis. Varuzhanyan G, et al. J Cell Sci, 2020 Jul 16. PMID 32675215, Free PMC Article
    4. Mitochondrial morphogenesis: fusion factor for fly fertility. Yaffe MP. Curr Biol, 1997 Dec 1. PMID 9382824
    5. A fuzzy mitochondrial fusion apparatus comes into focus. Mozdy AD, et al. Nat Rev Mol Cell Biol, 2003 Jun. PMID 12778126

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Nebenkern assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrion localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fuzzy onions
    Names
    CG4568-PA
    fzo-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23201644..23204034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170060.2 → NP_732840.1  fuzzy onions [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732840.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18412, Q4V3Y6, Q9VCP7
      Related
      FBpp0083791
      Conserved Domains (2) summary
      cd09912
      Location:87 → 334
      DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
      pfam04799
      Location:572 → 716
      Fzo_mitofusin; fzo-like conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18412.2 O18412

    Gene LinkOut

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