Pi3K92E Phosphatidylinositol 3-kinase 92E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pi3K92Eprovided by FlyBase
Official Full Name: Phosphatidylinositol 3-kinase 92Eprovided by FlyBase
Primary source: FLYBASE:FBgn0015279
Locus tag: Dmel_CG4141
See related: AllianceGenome:FB:FBgn0015279
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-92Ed; CG4141; Dmel\CG4141; Dmp110; dp110; dP110; Dp110; DP110; Dp110/PI3K; dp110alpha; dP13K; dPI3K; dPI3K[92E]; dpP110; Dpp110; p110; p120; PI(3)K; PI-3 kinase; PI-3-K; PI3'K; pi3k; pI3K; Pi3k; Pi3K; PI3k; PI3K; PI3K dp110; PI3K-92D; PI3K-92E/Dp110; PI3K-cat; PI3K-dp110; PI3K-Dp110; PI3K-I; Pi3K92D; pi3k92e; pi3k92E; Pi3k92e; Pi3k92E; PI3K92E; Pi3Kp110; Pi3ks; PiK92E; PI[[3]]K; rea; type-1 PI3K
Summary: Enables 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of developmental growth; and positive regulation of hemocyte differentiation. Part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in adult head; organism; and ventral furrow. Used to study alcohol use disorder; cancer (multiple); glucose metabolism disease (multiple); and heart disease. Human ortholog(s) of this gene implicated in colorectal cancer; glioblastoma; immunodeficiency 14; reproductive organ cancer (multiple); and schizophrenia. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) and PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 92F3-92F3; 3-69 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20628972..20634732, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16454694..16460454, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

InR and Pi3K maintain intestinal homeostasis through STAT/EGFR and Notch signaling in enteroblasts.
Title: InR and Pi3K maintain intestinal homeostasis through STAT/EGFR and Notch signaling in enteroblasts.
Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity.
Title: Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity.
PI3K activation prevents Abeta42-induced synapse loss and favors insoluble amyloid deposit formation.
Title: PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation.
The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth.
Title: The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth.
results indicate a novel kinase-independent function of the PI3K catalytic subunit.
Title: The Unique Non-Catalytic C-Terminus of P37delta-PI3K Adds Proliferative Properties In Vitro and In Vivo.
class I PI3K and PI(3,4,5)P(3) may be involved in the regulation of invagination during gastrulation
Title: Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Title: Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone H4 at lysine 16.
p53-related protein kinase is required for PI3K/TOR pathway-dependent growth.
Title: Drosophila p53-related protein kinase is required for PI3K/TOR pathway-dependent growth.
PI3K requires Ras activity to decrease motor neuron excitability whereas the ability of PI3K to increase nerve terminal growth is Ras-independent.
Title: Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons.
PI3K-Akt-TOR pathway is an important regulator of sindbis virus replication in mosquito cells and Drosophila.
Title: Role for the phosphatidylinositol 3-kinase-Akt-TOR pathway during sindbis virus replication in arthropods.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in entry into diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structural plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IPI Inferred from Physical Interaction more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatidylinositol 3-kinase 92E

Names: CG4141-PA; CG4141-PB; CG4141-PC; PI 3-kinase; PI3 kinase; PI3-kinase; PI3K; PI3K class I; PI3Kinase92E; Phosphatidylinositol-3-kinase; Phosphoinositide-3 kinase; Pi3K92E-PA; Pi3K92E-PB; Pi3K92E-PC; class I PI(3)K; dPI 3-kinase; insulin-regulated PI3 kinase; p110 PI3 kinase; phosphatidylinositol 3-kinase; phosphatidylinositol-3 kinase; phospho-inositol-3 kinase at 92E; phosphoinositide 3 kinase Dp110; phosphoinositide 3-kinase; phosphotidylinositol 3 kinase

NP_001262770.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

NP_650902.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

NP_732536.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20628972..20634732 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169910.2 → NP_732536.1 phosphatidylinositol 3-kinase 92E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732536.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZY88, H1ZY91, P91634

Related

FBpp0083349

Conserved Domains (5) summary

cd08693
Location:339 → 517

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:200 → 307

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:552 → 723

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05165
Location:727 → 1084

PI3Kc_I; Catalytic domain of Class I Phosphoinositide 3-kinase

cl02483
Location:56 → 132

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_142645.3 → NP_650902.1 phosphatidylinositol 3-kinase 92E, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650902.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZY88, H1ZY91, P91634

Related

FBpp0083348

Conserved Domains (5) summary

cd08693
Location:339 → 517

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:200 → 307

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:552 → 723

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05165
Location:727 → 1084

PI3Kc_I; Catalytic domain of Class I Phosphoinositide 3-kinase

cl02483
Location:56 → 132

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_001275841.1 → NP_001262770.1 phosphatidylinositol 3-kinase 92E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262770.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZY88, H1ZY91, P91634

Conserved Domains (5) summary

cd08693
Location:339 → 517

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:200 → 307

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:552 → 723

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05165
Location:727 → 1084

PI3Kc_I; Catalytic domain of Class I Phosphoinositide 3-kinase

cl02483
Location:56 → 132

PI3K_p85B; PI3-kinase family, p85-binding domain