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    TfIIEbeta Transcription factor IIEbeta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TfIIEbetaprovided by FlyBase
    Official Full Name
    Transcription factor IIEbetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015829
    Locus tag
    Dmel_CG1276
    See related
    AllianceGenome:FB:FBgn0015829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1276; Dmel\CG1276; dTFIIE-S; dTFIIES; E[[S]]; TFIIbeta; TfIIE; TFIIE; TFIIEbeta
    Summary
    Predicted to contribute to TFIIH-class transcription factor complex binding activity. Involved in mRNA transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIE complex. Is expressed in organism. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TfIIEbeta in Genome Data Viewer
    Location:
    64A12-64A12; 3-10 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4287038..4288349)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4287038..4288349)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene shrew Neighboring gene uncharacterized protein Neighboring gene Hexosaminidase 1 Neighboring gene uncharacterized protein Neighboring gene Ferredoxin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila TFIIE: purification, cloning, and functional reconstitution. Wang X, et al. Proc Natl Acad Sci U S A, 1997 Jan 21. PMID 9012800, Free PMC Article
    2. Transcription. Dichotomous regulators. Roberts SG, et al. Nature, 1995 May 11. PMID 7753162
    3. Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity. Jiménez-Mejía G, et al. Hereditas, 2022 May 30. PMID 35637493, Free PMC Article
    4. Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila. Altamirano-Torres C, et al. PLoS One, 2018. PMID 30321227, Free PMC Article
    5. Control of transcription by Krüppel through interactions with TFIIB and TFIIE beta. Sauer F, et al. Nature, 1995 May 11. PMID 7753175

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trimeric complexes of Antp-TBP with TFIIEbeta or Exd modulate transcriptional activity.
      Title: Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity.
    2. interaction of Antp with TFIIEbeta is important for the functional specificity of Antennapedia, and amino acids 32 and 36 in Antp HD helix 2 are key for this interaction
      Title: Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to TFIIH-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIE complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIIE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor IIEbeta
    Names
    CG1276-PA
    CG1276-PB
    TFIIE small subunit
    TfIIEbeta-PA
    TfIIEbeta-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4287038..4288349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169875.1 → NP_001163346.1  transcription factor IIEbeta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIC9
      Conserved Domains (1) summary
      cd07977
      Location:18 → 98
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity

    2. NM_079199.3 → NP_523923.1  transcription factor IIEbeta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96881
      Related
      FBpp0073090
      Conserved Domains (1) summary
      cd07977
      Location:61 → 141
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIC9 E1JIC9
    O96881 O96881

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