U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Acp62F Accessory gland protein 62F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38340, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Acp62Fprovided by FlyBase
    Official Full Name
    Accessory gland protein 62Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020509
    Locus tag
    Dmel_CG1262
    See related
    AllianceGenome:FB:FBgn0020509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acp62; Acp62f; CG1262; CT2528; Dmel\CG1262
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis and sperm competition. Located in extracellular space. Is expressed in several structures, including adult hemolymph; female reproductive system; ovary; oviduct; and sperm storage organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Acp62F in Genome Data Viewer
    Location:
    62F2-62F2; 3-4 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2739750..2740228)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2739750..2740228)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fife Neighboring gene uncharacterized protein Neighboring gene Myocardin-related transcription factor Neighboring gene Adenosylhomocysteinase like 1 Neighboring gene Novel nucleolar protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Selection on the Drosophila seminal fluid protein Acp62F. Wong A, et al. Ecol Evol, 2013 Jul. PMID 23919141, Free PMC Article
    2. Identification and characterization of the major Drosophila melanogaster mating plug protein. Lung O, et al. Insect Biochem Mol Biol, 2001 Apr 27. PMID 11267893
    3. Drosophila seminal fluid proteins enter the circulatory system of the mated female fly by crossing the posterior vaginal wall. Lung O, et al. Insect Biochem Mol Biol, 1999 Dec. PMID 10612039
    4. The Drosophila seminal fluid protein Acp26Aa stimulates release of oocytes by the ovary. Heifetz Y, et al. Curr Biol, 2000 Jan 27. PMID 10662669
    5. The gifts that keep on giving: physiological functions and evolutionary dynamics of male seminal proteins in Drosophila. Wolfner MF. Heredity (Edinb), 2002 Feb. PMID 11932766

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The reproductive functions of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F was analysed by generating a precise deletion of the Acp62F gene.
      Title: Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F.
    2. a candidate for a molecule to contribute to the Acp-dependent decrease in female life span
      Title: The Drosophila melanogaster seminal fluid protein Acp62F is a protease inhibitor that is toxic upon ectopic expression.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sperm competition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    accessory gland protein 62F
    Names
    Acp62F-PA
    CG1262-PA
    accessory gland peptide 62F

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2739750..2740228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079168.3 → NP_523892.1  accessory gland protein 62F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46202
      UniProtKB/TrEMBL
      Q1ECC5
      Related
      FBpp0072820
      Conserved Domains (1) summary
      pfam01826
      Location:34 → 88
      TIL; Trypsin Inhibitor like cysteine rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46202.1 O46202

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools