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    Nep1 Neprilysin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nep1provided by FlyBase
    Official Full Name
    Neprilysin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029843
    Locus tag
    Dmel_CG5905
    See related
    AllianceGenome:FB:FBgn0029843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5894; CG5905; CG5914; Dmel\CG5905; DmeNEP1; dNEP1; NEP; nep1; NEP1
    Summary
    Predicted to enable metallopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain; adult head; adult midgut progenitor cell; embryonic/larval midgut; and epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2T; X-linked dominant hypophosphatemic rickets; cerebral amyloid angiopathy; membranous glomerulonephritis; and neurodegenerative disease (multiple). Orthologous to several human genes including MME (membrane metalloendopeptidase) and MMEL1 (membrane metalloendopeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nep1 in Genome Data Viewer
    Location:
    5D4-5D5; 1-15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6091205..6103971)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5985238..5998004)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44959 Neighboring gene uncharacterized protein Neighboring gene raptor Neighboring gene Multiple inositol polyphosphate phosphatase 2 Neighboring gene Ca[2+]-channel protein alpha[[1]] subunit T Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1. Turrel O, et al. J Neurosci, 2020 May 20. PMID 32303647, Free PMC Article
    2. Drosophila Neprilysin 1 Rescues Memory Deficits Caused by Amyloid-β Peptide. Turrel O, et al. J Neurosci, 2017 Oct 25. PMID 28931572, Free PMC Article
    3. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Turner AJ, et al. Bioessays, 2001 Mar. PMID 11223883
    4. Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory. Turrel O, et al. J Neurosci, 2016 Sep 14. PMID 27629706, Free PMC Article
    5. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model. Sun ZD, et al. Neural Regen Res, 2022 Oct. PMID 35259851, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neprilysin 1
    Names
    CG5905-PA
    CG5905-PB
    CG5905-PC
    CG5905-PD
    Nep1-PA
    Nep1-PB
    Nep1-PC
    Nep1-PD
    NP_001284925.1
    NP_001284926.1
    NP_511056.2
    NP_727065.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6091205..6103971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297997.1 → NP_001284926.1  neprilysin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284926.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    2. NM_167059.2 → NP_727065.1  neprilysin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727065.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Related
      FBpp0070837
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    3. NM_078501.3 → NP_511056.2  neprilysin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511056.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Related
      FBpp0070838
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    4. NM_001297996.1 → NP_001284925.1  neprilysin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W436.2 Q9W436

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