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    kdn knockdown [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kdnprovided by FlyBase
    Official Full Name
    knockdownprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261955
    Locus tag
    Dmel_CG3861
    See related
    AllianceGenome:FB:FBgn0261955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GM01832; CG 3861; CG3861; CS; csyn; Csyn; Dmel\CG3861; Kdn; l (1) G0030; l(1)G0030; l(1)G0033; l(1)G0159
    Summary
    Enables citrate (Si)-synthase activity. Predicted to be involved in carbohydrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; anal pad primordium; embryonic/larval midgut primordium; and ganglia. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kdn in Genome Data Viewer
    Location:
    5F2-5F4; 1-16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6350629..6361323)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6244662..6255356)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B16.6 subunit Neighboring gene swallow pseudogene Neighboring gene swallow

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Rao RP, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592126, Free PMC Article
    2. Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Schwarze SR, et al. Free Radic Biol Med, 1998 Oct. PMID 9801075
    3. A Colorimetric Assay of Citrate Synthase Activity in Drosophila Melanogaster. Wei P, et al. J Vis Exp, 2020 Jan 16. PMID 32009637
    4. Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster. Simard C, et al. Metabolites, 2020 Sep 6. PMID 32899962, Free PMC Article
    5. Technical knockout, a Drosophila model of mitochondrial deafness. Toivonen JM, et al. Genetics, 2001 Sep. PMID 11560901, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate (Si)-synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables citrate (Si)-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables citrate (Si)-synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    knockdown
    Names
    CG3861-PA
    CG3861-PB
    citrate synthase
    kdn-PA
    kdn-PB
    lethal (1) G0030
    NP_572319.2
    NP_727091.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6350629..6361323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167072.2 → NP_727091.1  knockdown, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP50
      Related
      FBpp0070871
      Conserved Domains (2) summary
      cd06105
      Location:92 → 519
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:89 → 513
      PLN02456; citrate synthase

    2. NM_132091.3 → NP_572319.2  knockdown, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572319.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T477, Q9W401
      UniProtKB/TrEMBL
      C6TP50
      Related
      FBpp0070872
      Conserved Domains (2) summary
      cd06105
      Location:34 → 461
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:7 → 455
      PLN02456; citrate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9J9 Q8T9J9
    Q9W401.1 Q9W401

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