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    Ldsdh1 Lipid droplet subset dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ldsdh1provided by FlyBase
    Official Full Name
    Lipid droplet subset dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029994
    Locus tag
    Dmel_CG2254
    See related
    AllianceGenome:FB:FBgn0029994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2254; Dmel\CG2254
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Located in endoplasmic reticulum and lipid droplet. Is expressed in adult head; adult heart; embryonic/larval anterior midgut; embryonic/larval corpus allatum; and embryonic/larval fat body. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13); and RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ldsdh1 in Genome Data Viewer
    Location:
    7D5-7D5; 1-22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8078350..8081605, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7972383..7975638, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Upf2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45535 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin conjugating enzyme E2H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting of the Drosophila protein CG2254/Ldsdh1 to a subset of lipid droplets. Thul PJ, et al. J Cell Sci, 2017 Sep 15. PMID 28775149
    2. PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Beller M, et al. Cell Metab, 2010 Nov 3. PMID 21035762
    3. The contribution of the Drosophila model to lipid droplet research. Kühnlein RP. Prog Lipid Res, 2011 Oct. PMID 21620889
    4. The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains. Santana JF, et al. Cell Rep, 2020 Mar 10. PMID 32160531, Free PMC Article
    5. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipid droplet subset dehydrogenase 1
    Names
    CG2254-PA
    Ldsdh1-PA
    NP_572436.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8078350..8081605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132208.2 → NP_572436.1  lipid droplet subset dehydrogenase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWZ9, Q9W3K9
      Related
      FBpp0071071
      Conserved Domains (2) summary
      pfam00106
      Location:59 → 248
      adh_short; short chain dehydrogenase
      cl21454
      Location:60 → 287
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWZ9 Q8SWZ9
    Q9W3K9 Q9W3K9

    Gene LinkOut

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