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    Cht6 Chitinase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31935, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cht6provided by FlyBase
    Official Full Name
    Chitinase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0263132
    Locus tag
    Dmel_CG43374
    See related
    AllianceGenome:FB:FBgn0263132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15313; CG15314; CG2989; CG43374; Cht; cht6; CT5624; DmCht6; Dmel\CG43374
    Old locus tag
    Dmel_CG15313; Dmel_CG15314; Dmel_CG2989
    Summary
    Enables chitinase activity. Involved in chitin catabolic process; ecdysis, chitin-based cuticle; and regulation of tube size, open tracheal system. Predicted to be active in extracellular region. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Cht6 in Genome Data Viewer
    Location:
    9A4-9A5; 1-30 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10016845..10050803)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9910878..9944836)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene antisense RNA:CR45185 Neighboring gene antisense RNA:CR45601 Neighboring gene Yolk protein 2 Neighboring gene Yolk protein 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chitin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chitinase 6
    Names
    CG43374-PC
    CG43374-PF
    CG43374-PG
    CG43374-PH
    CG43374-PI
    CG43374-PJ
    CG43374-PK
    Cht6-PC
    Cht6-PF
    Cht6-PG
    Cht6-PH
    Cht6-PI
    Cht6-PJ
    Cht6-PK
    NP_001096934.2
    NP_001245598.1
    NP_001245599.1
    NP_001245600.1
    NP_001245601.1
    NP_001245602.1
    NP_572598.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10016845..10050803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258673.2NP_001245602.1  chitinase 6, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGY0
      Conserved Domains (4) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain
      cl00492
      Location:26912750
      Oxidored_q2; NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
    2. NM_001258669.2NP_001245598.1  chitinase 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDS9
      Conserved Domains (4) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain
      cl00492
      Location:26912750
      Oxidored_q2; NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
    3. NM_001258671.2NP_001245600.1  chitinase 6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEC2
      Conserved Domains (3) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain
    4. NM_001258670.2NP_001245599.1  chitinase 6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NG70
      Conserved Domains (3) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain
    5. NM_132370.4NP_572598.3  chitinase 6, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572598.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2Z3
      Conserved Domains (4) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain
      cl00492
      Location:26912750
      Oxidored_q2; NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
    6. NM_001258672.2NP_001245601.1  chitinase 6, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF05
      Conserved Domains (3) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain
    7. NM_001103464.3NP_001096934.2  chitinase 6, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096934.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUP3
      Conserved Domains (3) summary
      cd02872
      Location:32404
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31383
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:506562
      CBM_14; Chitin binding Peritrophin-A domain