hep hemipterous [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hepprovided by FlyBase
Official Full Name: hemipterousprovided by FlyBase
Primary source: FLYBASE:FBgn0010303
Locus tag: Dmel_CG4353
See related: AllianceGenome:FB:FBgn0010303
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7
Summary: Enables JUN kinase kinase activity; MAP-kinase scaffold activity; and protein kinase binding activity. Involved in several processes, including defense response to other organism; imaginal disc morphogenesis; and positive regulation of cellular component biogenesis. Located in axon. Is expressed in adult antennal lobe; adult brain; adult mushroom body; and organism. Used to study heart disease. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11D10-11D10; 1-41 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13079205..13090434, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12973238..12984467, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in Drosophila both MAPKKs, Hep/Mkk7 and Mkk4, are required to induce JNK upon TNF or pro-inflammatory stimulation
Title: A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.
Apoptotic cells can induce compensatory cell proliferation through the JNKK signaling pathway.
Title: Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables MAP-kinase scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in basement membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorion micropyle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorion-containing eggshell pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, spreading of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc eversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hemipterous

Names: CG4353-PA; CG4353-PC; CG4353-PD; CG4353-PE; CG4353-PF; CG4353-PG; CG4353-PH; JNK kinase; JNK-Kinase; Mitogen-activated protein kinase kinase 7; hemipterus; hempiterous; hep-PA; hep-PC; hep-PD; hep-PE; hep-PF; hep-PG; hep-PH

NP_001259500.1

EC 2.7.12.2

NP_001259501.1

EC 2.7.12.2

NP_001285182.1

EC 2.7.12.2

NP_001368981.1

EC 2.7.12.2

NP_001368982.1

EC 2.7.12.2

NP_511142.2

EC 2.7.12.2

NP_727661.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13079205..13090434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298253.1 → NP_001285182.1 hemipterous, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285182.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JJV1

Conserved Domains (2) summary

smart00220
Location:203 → 456

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001272571.2 → NP_001259500.1 hemipterous, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259500.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEF9

Conserved Domains (2) summary

smart00220
Location:203 → 456

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001382110.1 → NP_001368981.1 hemipterous, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EF36

Conserved Domains (1) summary

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001382111.1 → NP_001368982.1 hemipterous, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EEQ6

Conserved Domains (1) summary

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_167346.2 → NP_727661.1 hemipterous, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727661.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18411, Q23977, Q8SZ04, Q8SZZ1, Q9I7S3

Related

FBpp0073578

Conserved Domains (2) summary

smart00220
Location:203 → 456

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001272572.2 → NP_001259501.1 hemipterous, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259501.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH06

Conserved Domains (2) summary

smart00220
Location:203 → 456

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_078587.3 → NP_511142.2 hemipterous, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511142.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PH06

Related

FBpp0073579

Conserved Domains (2) summary

smart00220
Location:203 → 456

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:181 → 476

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7