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    CG9095 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9095provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030617
    Locus tag
    Dmel_CG9095
    See related
    AllianceGenome:FB:FBgn0030617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT26106; Dmel\CG9095
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); atypical hemolytic-uremic syndrome; autoimmune disease (multiple); and hemolytic-uremic syndrome. Orthologous to human CD46 (CD46 molecule); APOH (apolipoprotein H); and SELL (selectin L). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9095 in Genome Data Viewer
    Location:
    13B1-13B1; 1-50 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15139937..15163225, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15033970..15057258, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene drop dead Neighboring gene Ribosomal protein L37-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity. Dodd RB, et al. Glycobiology, 2001 May. PMID 11425795
    2. A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila. Aikin R, et al. PLoS One, 2012. PMID 22432040, Free PMC Article
    3. Comparative genomic analysis of C-type lectin-domain genes in seven holometabolous insect species. Lu Y, et al. Insect Biochem Mol Biol, 2020 Nov. PMID 32841718
    4. Participation of a galactose-specific C-type lectin in Drosophila immunity. Tanji T, et al. Biochem J, 2006 May 15. PMID 16475980, Free PMC Article
    5. The Drosophila Tis11 protein and its effects on mRNA expression in flies. Choi YJ, et al. J Biol Chem, 2014 Dec 19. PMID 25342740, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9095-PA
    CG9095-PB
    CG9095-PC
    CG9095-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15139937..15163225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132778.2 → NP_573006.1  uncharacterized protein Dmel_CG9095, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXX7
      Related
      FBpp0073843
      Conserved Domains (4) summary
      cd00033
      Location:500 → 556
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00034
      Location:256 → 375
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      pfam00084
      Location:381 → 435
      Sushi; Sushi repeat (SCR repeat)
      cl23730
      Location:94 → 242
      F5_F8_type_C; F5/8 type C domain

    2. NM_001272633.2 → NP_001259562.1  uncharacterized protein Dmel_CG9095, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHT4
      Conserved Domains (4) summary
      cd00033
      Location:500 → 556
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00034
      Location:256 → 375
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      pfam00084
      Location:381 → 435
      Sushi; Sushi repeat (SCR repeat)
      cl23730
      Location:94 → 242
      F5_F8_type_C; F5/8 type C domain

    3. NM_001298336.1 → NP_001285265.1  uncharacterized protein Dmel_CG9095, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBY1
      Conserved Domains (4) summary
      cd00033
      Location:500 → 556
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00034
      Location:256 → 375
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      pfam00084
      Location:381 → 435
      Sushi; Sushi repeat (SCR repeat)
      cl23730
      Location:94 → 242
      F5_F8_type_C; F5/8 type C domain

    4. NM_001103514.2 → NP_001096984.1  uncharacterized protein Dmel_CG9095, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096984.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUX3
      Conserved Domains (4) summary
      smart00607
      Location:94 → 242
      FTP; eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain
      cd00033
      Location:500 → 556
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00034
      Location:256 → 375
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      pfam00084
      Location:381 → 435
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUX3 A8JUX3
    M9PHT4 M9PHT4
    Q9VXX7 Q9VXX7
    X2JBY1 X2JBY1

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