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    kat80 katanin 80 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kat80provided by FlyBase
    Official Full Name
    katanin 80provided by FlyBase
    Primary source
    FLYBASE:FBgn0040207
    Locus tag
    Dmel_CG13956
    See related
    AllianceGenome:FB:FBgn0040207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13956; CG9910; Dmel\CG13956; kat-80; Kat-80; Kat80; Katanin80
    Summary
    Predicted to enable microtubule binding activity. Involved in dorsal appendage formation. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and nurse cell. Used to study microcephaly. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kat80 in Genome Data Viewer
    Location:
    14B7-14B7; 1-53 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16267007..16276180, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16161040..16170213, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U2 at 14B Neighboring gene uncharacterized protein Neighboring gene peroxisomal Multifunctional enzyme type 2 Neighboring gene Proteasome alpha4 subunit Neighboring gene easily shocked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The non-catalytic domains of Drosophila katanin regulate its abundance and microtubule-disassembly activity. Grode KD, et al. PLoS One, 2015. PMID 25886649, Free PMC Article
    2. Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Mishra-Gorur K, et al. Neuron, 2014 Dec 17. PMID 25521378, Free PMC Article
    3. Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases. Link N, et al. Development, 2020 Sep 28. PMID 32988995, Free PMC Article
    4. The origin and the mechanism of mechanical polarity during epithelial folding. Wang YC. Semin Cell Dev Biol, 2021 Dec. PMID 34059419
    5. Optimized RNA ISH, RNA FISH and protein-RNA double labeling (IF/FISH) in Drosophila ovaries. Zimmerman SG, et al. Nat Protoc, 2013 Nov. PMID 24113787, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    part_of katanin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of katanin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    katanin 80
    Names
    CG13956-PA
    CG13956-PB
    CG13956-PC
    Katanin80
    kat80-PA
    kat80-PB
    kat80-PC
    katanin
    katanin-80

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16267007..16276180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078639.3 → NP_523363.2  katanin 80, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523363.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHS0, Q8SXM2
      Related
      FBpp0074025
      Conserved Domains (4) summary
      COG2319
      Location:4 → 330
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam13925
      Location:667 → 803
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]

    2. NM_001298388.1 → NP_001285317.1  katanin 80, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXM2, X2JKM9
      Conserved Domains (4) summary
      COG2319
      Location:4 → 330
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam13925
      Location:666 → 802
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]

    3. NM_167488.2 → NP_727940.1  katanin 80, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHS0, Q8SXM2
      Related
      FBpp0074026
      Conserved Domains (4) summary
      COG2319
      Location:4 → 330
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam13925
      Location:667 → 803
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:22 → 58
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHS0 Q0KHS0
    Q8SXM2 Q8SXM2
    Q9NHF0 Q9NHF0
    X2JKM9 X2JKM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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