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    SkpC SKP1-related C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SkpCprovided by FlyBase
    Official Full Name
    SKP1-related Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026175
    Locus tag
    Dmel_CG11941
    See related
    AllianceGenome:FB:FBgn0026175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11941; Dmel\CG11941; dskpC; Skp; skpC
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SkpC in Genome Data Viewer
    Location:
    18F2-18F2; 1-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19816072..19816700)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19710105..19710733)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44885 Neighboring gene SKP1-related D Neighboring gene SKP1-related E Neighboring gene pico

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy TD. J Cell Sci, 2003 Jun 1. PMID 12730292
    2. RNA degradation is required for the germ-cell to maternal transition in Drosophila. Blatt P, et al. Curr Biol, 2021 Jul 26. PMID 33989522, Free PMC Article
    3. Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. Roberts DM, et al. PLoS One, 2012. PMID 22359584, Free PMC Article
    4. The E3 ligase Poe promotes Pericentrin degradation. Galletta BJ, et al. Mol Biol Cell, 2023 Aug 1. PMID 37342879, Free PMC Article
    5. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SKP1-related C
    Names
    CG11941-PA
    SkpC-PA
    skpC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19816072..19816700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134514.2 → NP_608358.1  SKP1-related C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHQ2, Q9VWC4
      Related
      FBpp0074566
      Conserved Domains (2) summary
      smart00512
      Location:6 → 114
      Skp1; Found in Skp1 protein family
      pfam01466
      Location:88 → 146
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWC4 Q9VWC4

    Gene LinkOut

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