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    CG17065 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17065provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031099
    Locus tag
    Dmel_CG17065
    See related
    AllianceGenome:FB:FBgn0031099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Amdhd2; Dmel\CG17065
    Summary
    Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process and negative regulation of UDP-N-acetylglucosamine biosynthetic process. Is expressed in embryonic/larval crystal cell; organism; procrystal cell; and yolk nucleus. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17065 in Genome Data Viewer
    Location:
    19C1-19C1; 1-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20254692..20257199, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20125718..20128225, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rab10 Neighboring gene uncharacterized protein Neighboring gene Innexin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
    2. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    3. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
    4. Hematopoietic plasticity mapped in Drosophila and other insects. Hultmark D, et al. Elife, 2022 Aug 3. PMID 35920811, Free PMC Article
    5. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-phosphate deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17065-PA
    CG17065-PB
    CG17065-PD
    NP_001162805.1
    NP_001285488.1
    NP_608380.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20254692..20257199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298559.1 → NP_001285488.1  uncharacterized protein Dmel_CG17065, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR81
      UniProtKB/TrEMBL
      X2JFY0
      Conserved Domains (2) summary
      COG1228
      Location:38 → 417
      HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
      cd00854
      Location:27 → 409
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

    2. NM_134536.3 → NP_608380.1  uncharacterized protein Dmel_CG17065, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR81
      UniProtKB/TrEMBL
      X2JFY0
      Related
      FBpp0077032
      Conserved Domains (2) summary
      COG1228
      Location:38 → 417
      HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
      cd00854
      Location:27 → 409
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

    3. NM_001169334.1 → NP_001162805.1  uncharacterized protein Dmel_CG17065, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJR9
      Conserved Domains (2) summary
      COG1228
      Location:38 → 431
      HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
      cd00854
      Location:27 → 423
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJR9 E1JJR9
    Q9VR81.1 Q9VR81
    X2JFY0 X2JFY0

    Gene LinkOut

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