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    Trf4 TBP-related factor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trf4provided by FlyBase
    Official Full Name
    TBP-related factor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0031444
    Locus tag
    Dmel_CG9879
    See related
    AllianceGenome:FB:FBgn0031444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9879; Dmel\CG9879; trf4
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription initiation. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trf4 in Genome Data Viewer
    Location:
    23A2-23A2; 2-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2665062..2666265)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2665062..2666265)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Proteasome beta4 subunit-related 1 Neighboring gene Proteasome beta4 subunit-related 2 Neighboring gene Odorant receptor 23a Neighboring gene pseudo Neighboring gene Gustatory receptor 23a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of gene regulation mechanisms during Drosophila spermatogenesis. Laktionov PP, et al. Epigenetics Chromatin, 2018 Apr 2. PMID 29609617, Free PMC Article
    2. TRF4, the novel TBP-related protein of Drosophila melanogaster, is concentrated at the endoplasmic reticulum and copurifies with proteins participating in the processes associated with endoplasmic reticulum. Kurshakova MM, et al. J Cell Biochem, 2019 May. PMID 30426565
    3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBP-related factor 4
    Names
    CG9879-PA
    Trf4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2665062..2666265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134855.2 → NP_608699.1  TBP-related factor 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGV8, Q9VQE6
      Related
      FBpp0077384
      Conserved Domains (2) summary
      PLN00062
      Location:131 → 294
      PLN00062; TATA-box-binding protein; Provisional
      pfam00352
      Location:213 → 291
      TBP; Transcription factor TFIID (or TATA-binding protein, TBP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQE6 Q9VQE6

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