ed echinoid [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: edprovided by FlyBase
Official Full Name: echinoidprovided by FlyBase
Primary source: FLYBASE:FBgn0000547
Locus tag: Dmel_CG12676
See related: AllianceGenome:FB:FBgn0000547
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1X5; CG12676; CG15424; CG16842; CT13476; CT35484; Dmel\CG12676; E(Elp)24D; E(Elp)[24D]; Echinoid; Ed; EN2-7; l(2)k01102
Summary: Enables cell adhesion molecule binding activity and epidermal growth factor receptor binding activity. Involved in several processes, including morphogenesis of an epithelium; negative regulation of cell differentiation; and regulation of signal transduction. Located in several cellular components, including adherens junction; cell surface; and early endosome. Is expressed in several structures, including epithelium; gut section; head epidermis primordium; main body follicle cell; and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 24D4-24D6; 2-11 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4031377..4115749)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4031377..4115749)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, our results demonstrate that transcriptional repression of Ed followed by Smurf-mediated downregulation of pretranslated Ed in amnioserosa regulates the establishment of a taut leading edge during dorsal closure
Title: Smurf Downregulates Echinoid in the Amnioserosa To Regulate Drosophila Dorsal Closure.
Data propose that Ed-mediated cell sorting is driven both by differential Ed adhesion that induces cell segregation with a jagged border and by actomyosin cable assembly at the interface that smoothens this border.
Title: Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting.
The planar polarized distribution of Echinoid in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties.
Title: Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure.
Data show that tracheal-specific expression of Echinoid rescues cell fusion defects, indicating that Ed acts in the trachea to control fusion cell fate.
Title: Echinoid regulates tracheal morphology and fusion cell fate in Drosophila.
Co-endocytosis of Ed and Fmi provides a link between apicobasal polarity and planar cell polarity.
Title: Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye.
differential levels of Ed and Fred between stationary and rotating cells at the initiation of rotation create a permissive environment for cell movement, and uniform levels in these two populations later contribute to stopping the movement
Title: The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye.
Data suggest that Echinoid mediates the dimerization of myosin VI/Jaguar in vivo which in turn regulates the reorganization and/or contraction of actin filaments to control changes in cell shape.
Title: Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila.
antagonizes the bristle-promoting activity of the Egfr pathway, either by the enhancement of Notch signalling or, similar to the eye, by a more direct action on the Egfr pathway
Title: Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning.
role of Ed during embryonic nervous system development, as well as adult sensory bristle specification; interacts synergistically with the Notch signaling pathway
Title: Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway.
results suggest a model in which neuroglian acts as a heterophilic ligand and activator of echinoid, which in turn antagonizes EGFR signaling
Title: Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in contractile actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of R8 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fusion cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization by cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	HDA more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: echinoid

Names: CG12676-PA; CG12676-PB; CG12676-PC; ed-PA; ed-PB; ed-PC; enhancer of NA9 2-7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

4031377..4115749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273084.1 → NP_001260013.1 echinoid, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260013.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9BN17, Q9VQW7

Conserved Domains (8) summary

cd00096
Location:656 → 734

Ig; Immunoglobulin domain

smart00408
Location:268 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:654 → 736

IG_like; Immunoglobulin like

cd00063
Location:741 → 848

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:146 → 249

I-set; Immunoglobulin I-set domain

pfam13895
Location:437 → 514

Ig_2; Immunoglobulin domain

pfam13927
Location:341 → 406

Ig_3; Immunoglobulin domain

cl11960
Location:168 → 249

Ig; Immunoglobulin domain
NM_001273085.1 → NP_001260014.1 echinoid, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260014.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCI6, Q9BN17

Conserved Domains (8) summary

cd00096
Location:656 → 734

Ig; Immunoglobulin domain

smart00408
Location:268 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:654 → 736

IG_like; Immunoglobulin like

cd00063
Location:741 → 848

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:146 → 249

I-set; Immunoglobulin I-set domain

pfam13895
Location:437 → 514

Ig_2; Immunoglobulin domain

pfam13927
Location:341 → 406

Ig_3; Immunoglobulin domain

cl11960
Location:168 → 249

Ig; Immunoglobulin domain
NM_078745.3 → NP_523469.2 echinoid, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523469.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9BN17, Q9VQW7

Related

FBpp0077154

Conserved Domains (8) summary

cd00096
Location:656 → 734

Ig; Immunoglobulin domain

smart00408
Location:268 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:654 → 736

IG_like; Immunoglobulin like

cd00063
Location:741 → 848

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:146 → 249

I-set; Immunoglobulin I-set domain

pfam13895
Location:437 → 514

Ig_2; Immunoglobulin domain

pfam13927
Location:341 → 406

Ig_3; Immunoglobulin domain

cl11960
Location:168 → 249

Ig; Immunoglobulin domain