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    LManVI Lysosomal alpha-mannosidase VI [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LManVIprovided by FlyBase
    Official Full Name
    Lysosomal alpha-mannosidase VIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032069
    Locus tag
    Dmel_CG9468
    See related
    AllianceGenome:FB:FBgn0032069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9468; Dmel\CG9468
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in adult head; embryonic/larval midgut; embryonic/larval posterior spiracle; and posterior spiracle primordium. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LManVI in Genome Data Viewer
    Location:
    29F1-29F1; 2-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8777661..8781252, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8777661..8781252, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lysosomal alpha-mannosidase IV Neighboring gene Lysosomal alpha-mannosidase V Neighboring gene uncharacterized protein Neighboring gene SoxNeuro

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
    2. Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. Kemppainen E, et al. PLoS One, 2016. PMID 26812173, Free PMC Article
    3. Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. Yang H, et al. BMC Genomics, 2017 May 18. PMID 28521739, Free PMC Article
    4. Glucomannan Hydrolysate Promotes Gut Proliferative Homeostasis and Extends Life Span in Drosophila melanogaster. Si Y, et al. J Gerontol A Biol Sci Med Sci, 2019 Sep 15. PMID 30252027, Free PMC Article
    5. Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Picchio L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525904

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase VI
    Names
    CG9468-PA
    LManVI-PA
    NP_609253.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8777661..8781252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135409.3 → NP_609253.1  lysosomal alpha-mannosidase VI [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS44, Q9VLH9
      Related
      FBpp0079343
      Conserved Domains (3) summary
      cd10810
      Location:38 → 312
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:482 → 1002
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:359 → 434
      Alpha-mann_mid; Alpha mannosidase, middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS44 Q8MS44
    Q9VLH9 Q9VLH9

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