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    cmet CENP-meta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cmetprovided by FlyBase
    Official Full Name
    CENP-metaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040232
    Locus tag
    Dmel_CG6392
    See related
    AllianceGenome:FB:FBgn0040232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cenp-E; CENP-E; CENP-E meta; Cenp-M; Cenp-meta; CENP-Meta; CENP-META; CENPE; CENPmeta; Cenp_E; CG6392; Cmet; DmCmet; DmCmeta; Dmel\CG6392; KIF 10; KIF10; l(2)04431
    Summary
    Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Involved in mitotic metaphase chromosome alignment and regulation of cell cycle. Located in kinetochore. Is expressed in wing hinge primordium and wing pouch. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cmet in Genome Data Viewer
    Location:
    32E2-32E2; 2-44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11261026..11269002, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11261026..11269002, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ca2+-channel-protein-beta-subunit Neighboring gene Buddy of Hmr 2 Neighboring gene long non-coding RNA:CR43859 Neighboring gene abrupt Neighboring gene CENP-ana Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BubR1 and CENP-E have antagonistic effects upon the stability of microtubule-kinetochore attachments in Drosophila S2 cell mitosis. Maia AF, et al. Cell Cycle, 2007 Jun 1. PMID 17525528
    2. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Clemente-Ruiz M, et al. Cell Cycle, 2014. PMID 24626182, Free PMC Article
    3. Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosis. Civelekoglu-Scholey G, et al. Biophys J, 2006 Jun 1. PMID 16533843, Free PMC Article
    4. Cenp-meta is required for sustained spindle checkpoint. Rubin T, et al. Biol Open, 2014 May 29. PMID 24876387, Free PMC Article
    5. Chromosome motors on the move. From motion to spindle checkpoint activity. Brunet S, et al. EMBO Rep, 2001 Aug. PMID 11493594, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E motor.
      Title: Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes.
    2. Depletion of CENP-E or Nsl1-the latter mediating kinetochore targeting of Bub3-in epithelial tissues unable to activate the apoptotic program induces significant levels of aneuploidy and drives tumor-like growth.
      Title: Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.
    3. CENP-E appears to be required to destabilize kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E.
      Title: BubR1 and CENP-E have antagonistic effects upon the stability of microtubule-kinetochore attachments in Drosophila S2 cell mitosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CENP-meta
    Names
    CG6392-PC
    CG6392-PD
    CG6392-PE
    CG6392-PF
    Cenp-meta
    CenpMeta
    Kinesin2A
    cmet-PC
    cmet-PD
    cmet-PE
    cmet-PF
    NP_001260380.1
    NP_001260381.1
    NP_001260382.1
    NP_524993.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11261026..11269002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273453.1 → NP_001260382.1  CENP-meta, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFL9, Q9NCG0
      Conserved Domains (4) summary
      smart00129
      Location:8 → 328
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:625 → 1394
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22853
      Location:8 → 321
      Motor_domain; Myosin and Kinesin motor domain
      pfam07851
      Location:724 → 812
      TMPIT; TMPIT-like protein

    2. NM_001273451.1 → NP_001260380.1  CENP-meta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD87, Q9NCG0
      Conserved Domains (4) summary
      smart00129
      Location:8 → 328
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:625 → 1394
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22853
      Location:8 → 321
      Motor_domain; Myosin and Kinesin motor domain
      pfam07851
      Location:724 → 812
      TMPIT; TMPIT-like protein

    3. NM_001273452.1 → NP_001260381.1  CENP-meta, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCX3, Q9NCG0
      Conserved Domains (5) summary
      pfam05483
      Location:1259 → 1925
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00129
      Location:8 → 328
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:680 → 1449
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22853
      Location:8 → 321
      Motor_domain; Myosin and Kinesin motor domain
      pfam07851
      Location:779 → 867
      TMPIT; TMPIT-like protein

    4. NM_080254.3 → NP_524993.3  CENP-meta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524993.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NCG0, Q9VKI0
      Conserved Domains (4) summary
      smart00129
      Location:8 → 328
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:680 → 1449
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22853
      Location:8 → 321
      Motor_domain; Myosin and Kinesin motor domain
      pfam07851
      Location:779 → 867
      TMPIT; TMPIT-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCX3 M9PCX3
    M9PD87 M9PD87
    M9PFL9 M9PFL9
    Q9NCG0 Q9NCG0
    Q9VKI0 Q9VKI0

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