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    DnaJ-H DnaJ homolog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34707, updated on 17-Dec-2024

    Summary

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    Official Symbol
    DnaJ-Hprovided by FlyBase
    Official Full Name
    DnaJ homologprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032474
    Locus tag
    Dmel_CG9828
    See related
    AllianceGenome:FB:FBgn0032474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9828; dDnaJ-H; dHdj2; Dmel\CG9828; DNA J-H; dnaJ-H; DNAJ-H; NEST:bs08d07
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval salivary gland; larval central nervous system; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DnaJ-H in Genome Data Viewer
    Location:
    34A7-34A7; 2-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13163209..13166072, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13163209..13166072, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Protein kinase at 34A Neighboring gene kumgang Neighboring gene Sirtuin 1 Neighboring gene Scm-related gene containing four mbt domains Neighboring gene antisense RNA:CR46256 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
    2. Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner. Whitaker R, et al. Aging (Albany NY), 2013 Sep. PMID 24036492, Free PMC Article
    3. A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Newman BL, et al. Genetics, 2002 Dec. PMID 12524341, Free PMC Article
    4. Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Chan HY, et al. Hum Mol Genet, 2000 Nov 22. PMID 11092757
    5. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DnaJ homolog
    Names
    CG9828-PA
    CG9828-PB
    CG9828-PC
    DnaJ-H-PA
    DnaJ-H-PB
    DnaJ-H-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13163209..13166072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273502.1 → NP_001260431.1  DnaJ homolog, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD23, Q8T922
      Conserved Domains (4) summary
      cd10719
      Location:134 → 197
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 363
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:5 → 64
      DnaJ; DnaJ domain

    2. NM_165025.2 → NP_723785.1  DnaJ homolog, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T922, Q9VK35
      Related
      FBpp0080071
      Conserved Domains (4) summary
      cd10719
      Location:134 → 197
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 363
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:5 → 64
      DnaJ; DnaJ domain

    3. NM_135761.3 → NP_609605.1  DnaJ homolog, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T922, Q9VK35
      Related
      FBpp0080072
      Conserved Domains (4) summary
      cd10719
      Location:134 → 197
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 363
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:5 → 64
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD23 M9PD23
    Q8T922 Q8T922
    Q9VK35 Q9VK35

    Gene LinkOut

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