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    Mtor mechanistic target of rapamycin kinase [ Mus musculus (house mouse) ]

    Gene ID: 56717, updated on 14-Jan-2025

    Summary

    Official Symbol
    Mtorprovided by MGI
    Official Full Name
    mechanistic target of rapamycin kinaseprovided by MGI
    Primary source
    MGI:MGI:1928394
    See related
    Ensembl:ENSMUSG00000028991 AllianceGenome:MGI:1928394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; 2610315D21Rik
    Summary
    Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and TORC2 signaling. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex and TORC2 complex. Colocalizes with PML body. Is expressed in several structures, including central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.0), kidney adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtor in Genome Data Viewer
    Location:
    4 E2; 4 78.76 cM
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148533039..148642142)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148448582..148557685)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E103 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene predicted gene, 23303 Neighboring gene angiopoietin-like 7 Neighboring gene STARR-positive B cell enhancer ABC_E1668 Neighboring gene predicted gene, 24002 Neighboring gene predicted gene, 23318 Neighboring gene exosome component 10 Neighboring gene spermidine synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (39 hits/119 screens)

    Associated conditions

    Description Tests
    flat-top
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC118056

    Gene Ontology Provided by MGI

    Items 1 - 25 of 44
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables RNA polymerase III type 1 promoter sequence-specific DNA binding  
    enables RNA polymerase III type 1 promoter sequence-specific DNA binding  
    enables RNA polymerase III type 2 promoter sequence-specific DNA binding  
    enables RNA polymerase III type 2 promoter sequence-specific DNA binding  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables TFIIIC-class transcription factor complex binding  
    enables TFIIIC-class transcription factor complex binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables inositol hexakisphosphate binding  
    enables metal ion binding  
    enables phosphoprotein binding  
    enables phosphoprotein binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables ribosome binding PubMed 
    Items 1 - 25 of 44
    Items 1 - 25 of 174
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process PubMed 
    involved_in DNA damage response PubMed 
    involved_in T-helper 1 cell lineage commitment PubMed 
    involved_in TOR signaling PubMed 
    involved_in TOR signaling PubMed 
    involved_in TOR signaling  
    involved_in TOR signaling  
    involved_in TORC1 signaling  
    acts_upstream_of_or_within TORC1 signaling PubMed 
    involved_in TORC1 signaling  
    involved_in TORC1 signaling  
    involved_in TORC2 signaling PubMed 
    acts_upstream_of_or_within TORC2 signaling PubMed 
    involved_in TORC2 signaling  
    involved_in behavioral response to pain PubMed 
    acts_upstream_of calcineurin-NFAT signaling cascade PubMed 
    involved_in cardiac cell development PubMed 
    acts_upstream_of_or_within cardiac muscle cell development PubMed 
    acts_upstream_of_or_within cardiac muscle contraction PubMed 
    acts_upstream_of_or_within cardiac muscle tissue development PubMed 
    acts_upstream_of_or_within cell projection organization PubMed 
    acts_upstream_of_or_within cell projection organization PubMed 
    involved_in cellular response to L-leucine  
    involved_in cellular response to L-leucine  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to leucine starvation  
    involved_in cellular response to leucine starvation  
    involved_in cellular response to methionine  
    involved_in cellular response to methionine  
    involved_in cellular response to nutrient  
    involved_in cellular response to nutrient levels PubMed 
    involved_in cellular response to nutrient levels  
    involved_in cellular response to nutrient levels PubMed 
    involved_in cellular response to osmotic stress PubMed 
    involved_in cellular response to starvation  
    involved_in chromatin remodeling  
    involved_in cytoskeleton organization PubMed 
    acts_upstream_of_or_within energy reserve metabolic process PubMed 
    acts_upstream_of_or_within germ cell development PubMed 
    acts_upstream_of_or_within heart morphogenesis PubMed 
    acts_upstream_of_or_within heart valve morphogenesis PubMed 
    involved_in inflammatory response PubMed 
    involved_in long-term memory  
    involved_in lysosome organization  
    involved_in lysosome organization  
    involved_in mRNA stabilization  
    acts_upstream_of macroautophagy PubMed 
    involved_in maternal process involved in female pregnancy  
    acts_upstream_of_or_within multicellular organism growth PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of autophagy PubMed 
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy PubMed 
    acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade PubMed 
    acts_upstream_of_or_within negative regulation of cell size PubMed 
    acts_upstream_of_or_within negative regulation of cell size PubMed 
    involved_in negative regulation of cholangiocyte apoptotic process  
    involved_in negative regulation of iodide transmembrane transport  
    involved_in negative regulation of lysosome organization  
    involved_in negative regulation of lysosome organization  
    involved_in negative regulation of macroautophagy  
    acts_upstream_of_or_within negative regulation of macroautophagy PubMed 
    acts_upstream_of_or_within negative regulation of macroautophagy PubMed 
    involved_in negative regulation of muscle atrophy  
    involved_in negative regulation of protein localization to nucleus  
    involved_in negative regulation of protein localization to nucleus  
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of protein ubiquitination  
    involved_in neuronal action potential PubMed 
    involved_in nucleus localization  
    involved_in nucleus localization  
    acts_upstream_of oligodendrocyte differentiation PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-serine phosphorylation  
    acts_upstream_of_or_within peptidyl-threonine phosphorylation PubMed 
    involved_in phosphorylation  
    acts_upstream_of_or_within positive regulation of actin filament polymerization PubMed 
    acts_upstream_of_or_within positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell growth involved in cardiac muscle cell development  
    involved_in positive regulation of cellular senescence  
    involved_in positive regulation of cholangiocyte proliferation  
    involved_in positive regulation of dendritic spine development  
    involved_in positive regulation of eating behavior  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of epithelial cell apoptotic process  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of glycolytic process PubMed 
    involved_in positive regulation of granulosa cell proliferation  
    involved_in positive regulation of keratinocyte migration  
    involved_in positive regulation of keratinocyte migration  
    acts_upstream_of_or_within positive regulation of lamellipodium assembly PubMed 
    involved_in positive regulation of lipid biosynthetic process PubMed 
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of lipid biosynthetic process PubMed 
    acts_upstream_of_or_within positive regulation of myotube differentiation PubMed 
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron maturation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of nitric oxide biosynthetic process  
    acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation PubMed 
    involved_in positive regulation of oligodendrocyte differentiation  
    involved_in positive regulation of pentose-phosphate shunt PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of protein kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of skeletal muscle hypertrophy  
    involved_in positive regulation of smooth muscle cell proliferation  
    acts_upstream_of_or_within positive regulation of stress fiber assembly PubMed 
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  
    involved_in positive regulation of translation  
    involved_in positive regulation of translational initiation  
    involved_in positive regulation of translational initiation  
    involved_in positive regulation of wound healing, spreading of epidermal cells  
    involved_in positive regulation of wound healing, spreading of epidermal cells  
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within protein autophosphorylation PubMed 
    acts_upstream_of protein destabilization  
    acts_upstream_of protein destabilization  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    acts_upstream_of_or_within regulation of GTPase activity PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of autophagosome assembly  
    involved_in regulation of autophagosome assembly  
    involved_in regulation of autophagy PubMed 
    involved_in regulation of brown fat cell differentiation  
    involved_in regulation of carbohydrate metabolic process  
    involved_in regulation of carbohydrate utilization  
    involved_in regulation of cell growth  
    involved_in regulation of cell size  
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of fatty acid beta-oxidation  
    involved_in regulation of glycogen biosynthetic process  
    involved_in regulation of locomotor rhythm PubMed 
    involved_in regulation of lysosome organization  
    acts_upstream_of_or_within regulation of membrane permeability PubMed 
    acts_upstream_of_or_within regulation of myelination PubMed 
    involved_in regulation of osteoclast differentiation PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within regulation of protein kinase activity PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation PubMed 
    involved_in regulation of response to food  
    involved_in regulation of translation at synapse, modulating synaptic transmission  
    acts_upstream_of_or_within response to amino acid PubMed 
    involved_in response to amino acid  
    involved_in response to cocaine  
    involved_in response to heat PubMed 
    acts_upstream_of_or_within response to insulin PubMed 
    involved_in response to nutrient  
    involved_in response to nutrient levels  
    involved_in rhythmic process  
    acts_upstream_of_or_within ruffle organization PubMed 
    involved_in social behavior  
    involved_in spinal cord development  
    involved_in visual learning  
    acts_upstream_of_or_within voluntary musculoskeletal movement PubMed 
    Items 1 - 25 of 174
    Items 1 - 20 of 37
    Component Evidence Code Pubs
    located_in Golgi membrane  
    colocalizes_with PML body PubMed 
    part_of TORC1 complex  
    part_of TORC1 complex PubMed 
    part_of TORC1 complex PubMed 
    part_of TORC2 complex  
    part_of TORC2 complex PubMed 
    part_of TORC2 complex PubMed 
    part_of TORC2 complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in cytosol  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in endomembrane system  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in glutamatergic synapse  
    is_active_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosomal membrane  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in mitochondrial outer membrane  
    located_in neuronal cell body  
    located_in nuclear envelope  
    located_in nuclear envelope  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    is_active_in postsynaptic cytosol  
    part_of protein-containing complex  
    Items 1 - 20 of 37

    General protein information

    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    FK506 binding protein 12-rapamycin associated protein 1
    FK506-binding protein 12-rapamycin complex-associated protein 1
    FKBP-rapamycin associated protein (FRAP)
    FKBP12-rapamycin complex-associated protein
    angiopoietin-like factor CDT6
    mammalian target of rapamycin
    mechanistic target of rapamycin (serine/threonine kinase)
    rapamycin target protein 1
    NP_064393.2
    XP_006539140.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020009.2NP_064393.2  serine/threonine-protein kinase mTOR

      Status: VALIDATED

      Source sequence(s)
      BC112904, CJ130100
      Consensus CDS
      CCDS18937.1
      UniProtKB/Swiss-Prot
      Q2KHT0, Q811J5, Q9CST1, Q9JLN9
      Related
      ENSMUSP00000099510.4, ENSMUST00000103221.10
      Conserved Domains (6) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05169
      Location:21532431
      PIKKc_TOR; Catalytic domain of Target of Rapamycin
      pfam02260
      Location:25182549
      FATC; FATC domain
      pfam08771
      Location:20152112
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      sd00044
      Location:655681
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148533039..148642142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539077.3XP_006539140.1  serine/threonine-protein kinase mTOR isoform X1

      Conserved Domains (2) summary
      COG5032
      Location:21829
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      sd00044
      Location:235261
      HEAT; HEAT repeat [structural motif]
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