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    Cyp301a1 Cytochrome P450 301a1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp301a1provided by FlyBase
    Official Full Name
    Cytochrome P450 301a1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033753
    Locus tag
    Dmel_CG8587
    See related
    AllianceGenome:FB:FBgn0033753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    301a1; CG8587; cutl; Cyp301A1; Dmel\CG8587
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in tergite morphogenesis. Is expressed in several structures, including adult integumentary system; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp301a1 in Genome Data Viewer
    Location:
    49B4-49B5; 2-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12566185..12569061)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8453690..8456566)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene frazzled Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenylate kinase 6 Neighboring gene stand still Neighboring gene Chloride channel-b Neighboring gene Sin3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytochrome p450 conserved in insects is involved in cuticle formation. Sztal T, et al. PLoS One, 2012. PMID 22574182, Free PMC Article
    2. Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila. Najarro MA, et al. PLoS Genet, 2015 Nov. PMID 26619284, Free PMC Article
    3. Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus. Brandt A, et al. Insect Mol Biol, 2002 Aug. PMID 12144699
    4. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
    5. dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing. Adler PN, et al. Dev Biol, 2013 Jul 1. PMID 23623898, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyp301a1 affects the formation of the adult cuticle in Drosophila melanogaster
      Title: A cytochrome p450 conserved in insects is involved in cuticle formation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tergite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 301a1
    Names
    CG8587-PA
    Cyp301a1-PA
    cytochrome P450
    NP_610796.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12566185..12569061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136952.3 → NP_610796.1  cytochrome P450 301a1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610796.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V6D6
      Related
      FBpp0086937
      Conserved Domains (1) summary
      cl12078
      Location:76 → 530
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V6D6.1 Q9V6D6

    Gene LinkOut

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