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    CG6472 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6472provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034166
    Locus tag
    Dmel_CG6472
    See related
    AllianceGenome:FB:FBgn0034166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6472
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6472 in Genome Data Viewer
    Location:
    53D15-53E1; 2-81 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16880713..16884695)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12768218..12772200)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-990 stem loop Neighboring gene inactivation no afterpotential C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl. Yao L, et al. Development, 2017 Sep 1. PMID 28760809, Free PMC Article
    2. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    3. Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. Napoletano F, et al. EMBO J, 2011 Mar 2. PMID 21278706, Free PMC Article
    4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6472-PB
    NP_611166.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16880713..16884695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137322.2 → NP_611166.2  uncharacterized protein Dmel_CG6472 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611166.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAL5
      Conserved Domains (1) summary
      cd00707
      Location:43 → 323
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAL5 A1ZAL5

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