Ipk1 Inositol phosphate kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ipk1provided by FlyBase
Official Full Name: Inositol phosphate kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0050295
Locus tag: Dmel_CG30295
See related: AllianceGenome:FB:FBgn0050295
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15228; CG15229; CG15230; CG30295; Dmel\CG30295; dmIpk1
Summary: Enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity. Involved in inositol phosphate biosynthetic process. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 57B3-57B4; 2-92 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (20870791..20879145)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (16758296..16766650)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the major route of IP6 synthesis depends on the activities of dmIpk2 and dmIpk1, but not dmIP3K, offering a new role for IP3K in the genesis of higher IP messengers
Title: A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol phosphate kinase 1

Names: CG30295-PA; CG30295-PB; CG30295-PC; CG30295-PD; Ipk1-PA; Ipk1-PB; Ipk1-PC; Ipk1-PD

NP_001097387.1

EC 2.7.1.158

NP_001261111.1

EC 2.7.1.158

NP_001286649.1

EC 2.7.1.158

NP_611522.1

EC 2.7.1.158

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

20870791..20879145

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103917.3 → NP_001097387.1 inositol phosphate kinase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097387.1

Status: REVIEWED

UniProtKB/TrEMBL

A8DYK1

Conserved Domains (1) summary

pfam06090
Location:51 → 332

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
NM_001274182.2 → NP_001261111.1 inositol phosphate kinase 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261111.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEV9

Conserved Domains (1) summary

pfam06090
Location:51 → 332

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
NM_137678.3 → NP_611522.1 inositol phosphate kinase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611522.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95R36, Q9W2Q7

Related

FBpp0071444

Conserved Domains (1) summary

pfam06090
Location:51 → 332

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
NM_001299720.1 → NP_001286649.1 inositol phosphate kinase 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286649.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LH15

Conserved Domains (1) summary

pfam06090
Location:85 → 192

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase