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    pirk poor Imd response upon knock-in [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pirkprovided by FlyBase
    Official Full Name
    poor Imd response upon knock-inprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034647
    Locus tag
    Dmel_CG15678
    See related
    AllianceGenome:FB:FBgn0034647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD16010; CG15678; Dmel\CG15678; pims; Pims; PIMS; Pirk; PIRK; rudra; Rudra
    Summary
    Enables signaling receptor binding activity. Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pirk in Genome Data Viewer
    Location:
    57F6-57F7; 2-96 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21660967..21662995, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17548472..17550500, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Inositol hexakisphosphate kinase Neighboring gene antisense RNA:CR43786 Neighboring gene NADH dehydrogenase (ubiquinone) B12 subunit Neighboring gene Rae1 Neighboring gene long non-coding RNA:CR44748 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anti-aging Effect of Agar Oligosaccharide on Male Drosophila melanogaster and its Preliminary Mechanism. Ma C, et al. Mar Drugs, 2019 Nov 6. PMID 31698828, Free PMC Article
    2. Interaction Between Familial Transmission and a Constitutively Active Immune System Shapes Gut Microbiota in Drosophila melanogaster. Mistry R, et al. Genetics, 2017 Jun. PMID 28413160, Free PMC Article
    3. Predicting structural features of selected flavonoids responsible for neuroprotection in a Drosophila model of Parkinson's disease. Maitra U, et al. Neurotoxicology, 2023 May. PMID 36822376, Free PMC Article
    4. A novel polyphenolic prebiotic and probiotic formulation have synergistic effects on the gut microbiota influencing Drosophila melanogaster physiology. Westfall S, et al. Artif Cells Nanomed Biotechnol, 2018. PMID 29644870
    5. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling. Kleino A, et al. Immunity, 2017 Oct 17. PMID 29045898, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poor Imd response upon knock-in
    Names
    CG15678-PA
    CG15678-PB
    PGRP-LC-interacting inhibitor of Imd signaling
    pirk-PA
    pirk-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21660967..21662995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299757.1 → NP_001286686.1  poor Imd response upon knock-in, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E6

    2. NM_137754.2 → NP_611598.1  poor Imd response upon knock-in, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E6
      Related
      FBpp0071599
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2E6 Q9W2E6

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