Il4ra interleukin 4 receptor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il4raprovided by MGI
Official Full Name: interleukin 4 receptor, alphaprovided by MGI
Primary source: MGI:MGI:105367
See related: Ensembl:ENSMUSG00000030748 AllianceGenome:MGI:105367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il4r; CD124
Summary: Predicted to enable interleukin-4 receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 39.6), adrenal adult (RPKM 36.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 68.94 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (125151443..125178646)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (125552271..125579474)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diminished gammadelta T Cells during Murine Allergic Skin Inflammation Is Mediated by IL-4 Signaling in Keratinocytes.
Title: Diminished γδ T Cells during Murine Allergic Skin Inflammation Is Mediated by IL-4 Signaling in Keratinocytes.
Global IL4Ralpha blockade exacerbates heart failure after an ischemic event in mice and humans.
Title: Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans.
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice.
Title: Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice.
IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin.
Title: IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin.
The IL-4Ralpha Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.
Title: The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.
IL-4Ralpha signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis.
Title: IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis.
A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit.
Title: A common IL-4 receptor variant promotes asthma severity via a T(reg) cell GRB2-IL-6-Notch4 circuit.
Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.
Title: Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.
IL4Ralpha signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity.
Title: IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity.
IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors.
Title: IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors.

Submit: New GeneRIF Correction See all GeneRIFs (124)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (11) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il4ra (e-PCR), detects polymorphism
- UniSTS:265225

Il4ra (e-PCR), detects polymorphism
- UniSTS:472913

Il4ra (e-PCR), detects polymorphism
- UniSTS:259182

PMC18827P1 (e-PCR)
- UniSTS:271740

M27960 (e-PCR)
- UniSTS:159686

Il4 (e-PCR), detects polymorphism
- UniSTS:143567

Il4ra (e-PCR), detects polymorphism
- UniSTS:256478

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-4 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-4 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of T-helper 1 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of T-helper 2 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-4-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T-helper 1 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in production of molecular mediator involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interleukin-4 receptor subunit alpha

Names: IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008700.4 → NP_001008700.1 interleukin-4 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_001008700.1

Status: VALIDATED

Source sequence(s)

AK159375, BC112911

Consensus CDS

CCDS40121.1

UniProtKB/Swiss-Prot

O54690, P16382, Q60583, Q8CBW5

UniProtKB/TrEMBL

Q3U905

Related

ENSMUSP00000033004.7, ENSMUST00000033004.8

Conserved Domains (2) summary

cd00063
Location:124 → 221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09238
Location:32 → 122

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
NM_001363983.1 → NP_001350912.1 interleukin-4 receptor subunit alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC125213

Conserved Domains (1) summary

cl26464
Location:211 → 475

Atrophin-1; Atrophin-1 family