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    rno rhinoceros [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnoprovided by FlyBase
    Official Full Name
    rhinocerosprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035106
    Locus tag
    Dmel_CG7036
    See related
    AllianceGenome:FB:FBgn0035106
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7036; Dmel\CG7036
    Summary
    Involved in compound eye photoreceptor development. Located in nucleus. Is expressed in spermatozoon. Orthologous to several human genes including JADE3 (jade family PHD finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rno in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (187207..199762, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (187207..199762, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MAP kinase-specific phosphatase Neighboring gene Mitochondrial carrier homolog 1 Neighboring gene mrityu Neighboring gene Glycerol kinase 1 Neighboring gene Nitrilase and fragile histidine triad fusion protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Farrell K, et al. Acta Neuropathol, 2022 Jan. PMID 34719765, Free PMC Article
    2. Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes. Platts AE, et al. Fly (Austin), 2009 Jul-Sep. PMID 19690466, Free PMC Article
    3. RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. Sukhanova MJ, et al. Dev Biol, 2011 Nov 15. PMID 21920355, Free PMC Article
    4. Probing the boundaries of orthology: the unanticipated rapid evolution of Drosophila centrosomin. Eisman RC, et al. Genetics, 2013 Aug. PMID 23749319, Free PMC Article
    5. Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Steele L, et al. Dev Biol, 2009 Nov 1. PMID 19744473, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide association study and functional validation implicates JADE1 in tauopathy.
      Title: Genome-wide association study and functional validation implicates JADE1 in tauopathy.
    2. Data show that the differentiation delay phenotype is caused by decreased levels of different components of the EGFR signaling pathway in the absence of rbf and rno.
      Title: RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye.
    3. Data show that removal of transcriptional activation of dE2F1 partially restores Delta expression in rbf,rno mutant clones and suppresses differentiation defects, indicating that this differentiation function of RBF is mediated by regulation of dE2F1.
      Title: Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhinoceros
    Names
    CG7036-PB
    CG7036-PC
    CG7036-PD
    rno-PB
    rno-PC
    rno-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      187207..199762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259599.2 → NP_001246528.1  rhinoceros, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDD8, Q7YZH1, Q9W0U2
      Conserved Domains (5) summary
      COG5141
      Location:250 → 664
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15573
      Location:314 → 359
      PHD_JADE; PHD finger found in proteins Jade-1, Jade-2, Jade-3, and similar proteins
      cd15707
      Location:367 → 480
      ePHD_RNO; Extended PHD finger found in Drosophila melanogaster PHD finger protein rhinoceros (RNO) and similar proteins
      pfam03153
      Location:2138 → 2295
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam10513
      Location:250 → 288
      EPL1; Enhancer of polycomb-like

    2. NM_206222.3 → NP_995944.1  rhinoceros, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDD8, Q7YZH1, Q9W0U2
      Conserved Domains (5) summary
      COG5141
      Location:250 → 664
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15573
      Location:314 → 359
      PHD_JADE; PHD finger found in proteins Jade-1, Jade-2, Jade-3, and similar proteins
      cd15707
      Location:367 → 480
      ePHD_RNO; Extended PHD finger found in Drosophila melanogaster PHD finger protein rhinoceros (RNO) and similar proteins
      pfam03153
      Location:2138 → 2295
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam10513
      Location:250 → 288
      EPL1; Enhancer of polycomb-like

    3. NM_138163.2 → NP_612007.2  rhinoceros, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612007.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NDD8, Q7YZH1, Q9W0U2
      Conserved Domains (5) summary
      COG5141
      Location:250 → 664
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15573
      Location:314 → 359
      PHD_JADE; PHD finger found in proteins Jade-1, Jade-2, Jade-3, and similar proteins
      cd15707
      Location:367 → 480
      ePHD_RNO; Extended PHD finger found in Drosophila melanogaster PHD finger protein rhinoceros (RNO) and similar proteins
      pfam03153
      Location:2138 → 2295
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam10513
      Location:250 → 288
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YZH1.1 Q7YZH1

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