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    Psf1 Partner of Sld Five 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psf1provided by FlyBase
    Official Full Name
    Partner of Sld Five 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035194
    Locus tag
    Dmel_CG9187
    See related
    AllianceGenome:FB:FBgn0035194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9187; CG9187-PA; Dmel\CG9187; psf1; PSF1
    Summary
    Predicted to be involved in DNA strand elongation involved in mitotic DNA replication. Part of CMG complex and GINS complex. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Psf1 in Genome Data Viewer
    Location:
    61F4-61F4; 3-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1246986..1247677, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1246986..1247677, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene galene Neighboring gene Kinesin-like protein at 61F Neighboring gene uncharacterized protein Neighboring gene Sac1 phosphatase Neighboring gene Booster for Crq

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
    2. Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression. Gosnell JA, et al. BMC Mol Biol, 2011 Apr 6. PMID 21470422, Free PMC Article
    3. The mechanism of DNA unwinding by the eukaryotic replicative helicase. Burnham DR, et al. Nat Commun, 2019 May 14. PMID 31089141, Free PMC Article
    4. Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase. Kose HB, et al. Nat Commun, 2020 Jul 24. PMID 32709841, Free PMC Article
    5. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Moyer SE, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798881, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
      Title: DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GINS complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    partner of Sld five 1
    Names
    CG9187-PA
    Psf1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1246986..1247677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138242.3 → NP_612086.1  partner of Sld five 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0I7
      Related
      FBpp0072615
      Conserved Domains (2) summary
      cd11710
      Location:9 → 134
      GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1
      cd21696
      Location:153 → 201
      GINS_B_Psf1; beta-strand (B) domain of GINS complex protein Psf1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0I7 Q9W0I7

    Gene LinkOut

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