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    cue cueball [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cueprovided by FlyBase
    Official Full Name
    cueballprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011204
    Locus tag
    Dmel_CG12086
    See related
    AllianceGenome:FB:FBgn0011204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12086; CT5570; Dmel\CG12086; ms(3)02509
    Summary
    Predicted to enable calcium ion binding activity. Involved in positive regulation of circadian sleep/wake cycle, sleep and triglyceride homeostasis. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cue in Genome Data Viewer
    Location:
    62A3-62A3; 3-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1503226..1517271, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1503226..1517271, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45812 Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU2-48 Neighboring gene half pint Neighboring gene Puromycin sensitive aminopeptidase Neighboring gene Increased minichromosome loss 1 Neighboring gene Ionotropic receptor 62a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity. Kruppa AJ, et al. Biochim Biophys Acta, 2013 Dec. PMID 23911349, Free PMC Article
    2. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. Hirst J, et al. BMC Cell Biol, 2011 May 20. PMID 21599933, Free PMC Article
    3. Ectopic expression screen identifies genes affecting Drosophila mesoderm development including the HSPG Trol. Trisnadi N, et al. G3 (Bethesda), 2014 Dec 23. PMID 25538103, Free PMC Article
    4. A fatty acid anabolic pathway in specialized-cells sustains a remote signal that controls egg activation in Drosophila. Poidevin M, et al. PLoS Genet, 2024 Mar. PMID 38483976, Free PMC Article
    5. Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Castrillon DH, et al. Genetics, 1993 Oct. PMID 8244010, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cueball
    Names
    CG12086-PA
    cue-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1503226..1517271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138269.3 → NP_612113.2  cueball [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612113.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RU0, Q9W0E5
      Related
      FBpp0072590
      Conserved Domains (2) summary
      smart00135
      Location:193 → 237
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam00058
      Location:167 → 208
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RU0.1 Q95RU0

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