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    Oseg2 Outer segment 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oseg2provided by FlyBase
    Official Full Name
    Outer segment 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035317
    Locus tag
    Dmel_CG13809
    See related
    AllianceGenome:FB:FBgn0035317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13809; Dmel\CG13809; IFT172; OSEG; oseg2; OSEG2; osm-1; OSM-1
    Summary
    Involved in intraciliary transport and non-motile cilium assembly. Located in non-motile cilium. Is expressed in larval antenno-maxillary sensory complex; second segment of antenna; sensory organ cell; and spermatozoon. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oseg2 in Genome Data Viewer
    Location:
    62D3-62D3; 3-2 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2229646..2235253)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2229646..2235253)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenylyl cyclase X D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
    2. Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. Benton R, et al. PLoS Biol, 2006 Feb. PMID 16402857, Free PMC Article
    3. MT-Nanotubes: Lifelines for Stem Cells. Amoyel M, et al. Cell Stem Cell, 2015 Aug 6. PMID 26253198
    4. Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages. Jana SC, et al. PLoS Genet, 2021 Aug. PMID 34411092, Free PMC Article
    5. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jékely G, et al. Bioessays, 2006 Feb. PMID 16435301

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cilium assembly ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of intraciliary transport particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer segment 2
    Names
    CG13809-PB
    Oseg2-PB
    osm-1
    selective LIM binding factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2229646..2235253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139443.2 → NP_647700.2  outer segment 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647700.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W040
      Conserved Domains (4) summary
      COG2319
      Location:19 → 325
      WD40; WD40 repeat [General function prediction only]
      PRK12798
      Location:1212 → 1393
      PRK12798; chemotaxis protein; Reviewed
      sd00039
      Location:19 → 63
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:18 → 313
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W040.3 Q9W040

    Gene LinkOut

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