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    rasp rasp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44098, updated on 17-Dec-2024

    Summary

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    Official Symbol
    raspprovided by FlyBase
    Official Full Name
    raspprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024194
    Locus tag
    Dmel_CG11495
    See related
    AllianceGenome:FB:FBgn0024194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7F21; CG11495; cmn; cnm; Dmel\CG11495; l(3)63Bg; l(3)m47; l(3)M47; l(3)SG3; Rasp; RASP; rsp; sig/ski; sit; ski; Ski; ski/sit
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including N-terminal peptidyl-L-cysteine N-palmitoylation; peptide hormone processing; and regionalization. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to several human genes including HHAT (hedgehog acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rasp in Genome Data Viewer
    Location:
    63B8-63B8; 3-6 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3162180..3163852)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3162180..3163852)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 30 kDa subunit Neighboring gene uncharacterized protein Neighboring gene ASCIZ zinc finger protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the mechanisms of protein palmitoylation. Linder ME, et al. Biochemistry, 2003 Apr 22. PMID 12693927
    2. Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase. Hardy RY, et al. J Biol Chem, 2012 Dec 14. PMID 23112049, Free PMC Article
    3. Model organisms lead the way to protein palmitoyltransferases. Linder ME, et al. J Cell Sci, 2004 Feb 1. PMID 14730009
    4. Hedgehog lipids: Promotors of alternative morphogen release and signaling?: Conflicting findings on lipidated Hedgehog transport and signaling can be explained by alternative regulated mechanisms to release the morphogen. Manikowski D, et al. Bioessays, 2021 Nov. PMID 34611914
    5. Hedgehog signaling: a tale of two lipids. Ingham PW. Science, 2001 Nov 30. PMID 11729305

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings define residues and regions within Shh that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation.
      Title: Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.
    2. Rasp-dependent acylation is necessary to generate a fully active Hh protein.
      Title: Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling.
    3. Rasp promotes palmitate addition to the N-terminal cysteine residue of Spitz, and this cysteine is required for Spitz activity in vivo
      Title: Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-L-cysteine N-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-terminal peptidyl-L-cysteine N-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor ligand maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in patched ligand maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in patched ligand maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc anterior/posterior pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rasp
    Names
    CG11495-PA
    central missing
    lethal(3)63Bg
    lethal(3)SG3
    rasp-PA
    sightless
    skinny hedgehog
    NP_523898.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3162180..3163852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079174.2 → NP_523898.1  rasp [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95VY0, Q9VZU2
      UniProtKB/TrEMBL
      H0RNG9
      Related
      FBpp0072893, FBtr0073029
      Conserved Domains (1) summary
      pfam03062
      Location:128 → 444
      MBOAT; MBOAT, membrane-bound O-acyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZU2.1 Q9VZU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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