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    Plppr5 phospholipid phosphatase related 5 [ Mus musculus (house mouse) ]

    Gene ID: 75769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plppr5provided by MGI
    Official Full Name
    phospholipid phosphatase related 5provided by MGI
    Primary source
    MGI:MGI:1923019
    See related
    Ensembl:ENSMUSG00000033342 AllianceGenome:MGI:1923019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lppr5; PRG-5; Pap2d; 4833424O15Rik
    Summary
    Predicted to enable phosphatidate phosphatase activity. Involved in positive regulation of filopodium assembly and positive regulation of neuron projection development. Located in plasma membrane. Is expressed in brain and cerebellum. Orthologous to human PLPPR5 (phospholipid phosphatase related 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.1), CNS E18 (RPKM 1.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plppr5 in Genome Data Viewer
    Location:
    3 G1; 3 51.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (117368274..117483157)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (117574608..117689508)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32216 Neighboring gene predicted gene, 40130 Neighboring gene STARR-seq mESC enhancer starr_08803 Neighboring gene STARR-seq mESC enhancer starr_08804 Neighboring gene phospholipid phosphatase related 4 Neighboring gene STARR-seq mESC enhancer starr_08806 Neighboring gene STARR-seq mESC enhancer starr_08807 Neighboring gene STARR-seq mESC enhancer starr_08808 Neighboring gene sorting nexin 7 Neighboring gene STARR-seq mESC enhancer starr_08809 Neighboring gene predicted gene, 52614 Neighboring gene STARR-seq mESC enhancer starr_08810 Neighboring gene predicted gene, 32344

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plppr5 gene inactivation causes a more severe neurological phenotype and abnormal mitochondrial homeostasis in a mouse model of juvenile seizure. Wang D, et al. Epilepsy Res, 2022 Jul. PMID 35617916
    2. Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons. Coiro P, et al. J Biol Chem, 2014 Sep 5. PMID 25074937, Free PMC Article
    3. Genetic Inhibition of Plppr5 Aggravates Hypoxic-Ischemie-Induced Cortical Damage and Excitotoxic Phenotype. Sun Y, et al. Front Neurosci, 2022. PMID 35401091, Free PMC Article
    4. Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice. Sun Y, et al. Front Endocrinol (Lausanne), 2021. PMID 33692754, Free PMC Article
    5. PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal Zinc Signaling-Mediated Mitochondrial Damage. Wang D, et al. Front Neurosci, 2021. PMID 34512249, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice.
      Title: Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model of plppr5-/- Mice.
    2. Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation.
      Title: Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons.
    3. Data show that PRG5 induces filopodia growth independently of Cdc42, and that axon collapse and RhoA activation induced by LPA and myelin-associated neurite inhibitor Nogo-A is attenuated in the presence of PRG5.
      Title: Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 5
    Names
    lipid phosphate phosphatase-related protein type 5
    phosphatidic acid phosphatase type 2d
    plasticity-related gene 5 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305451.1 → NP_001292380.1  phospholipid phosphatase-related protein type 5 isoform 1

      See identical proteins and their annotated locations for NP_001292380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116774, AC122030, AK032034, AK076176
      Consensus CDS
      CCDS80009.1
      UniProtKB/Swiss-Prot
      Q8BIL7, Q8BJ52, Q8K0B6, Q9D606
      UniProtKB/TrEMBL
      A0A5F8MPS1
      Related
      ENSMUSP00000102081.3, ENSMUST00000106473.5
      Conserved Domains (1) summary
      cd03384
      Location:118 → 267
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_029425.3 → NP_083701.2  phospholipid phosphatase-related protein type 5 isoform 2

      See identical proteins and their annotated locations for NP_083701.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC122030, AK014763, AK043629, BB351291, BB611685, BB622243, CB722774
      Consensus CDS
      CCDS17796.1
      UniProtKB/TrEMBL
      A0A5F8MPS1
      Related
      ENSMUSP00000045121.7, ENSMUST00000039564.11
      Conserved Domains (1) summary
      cd03384
      Location:118 → 267
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      117368274..117483157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163380.1 → XP_036019273.1  phospholipid phosphatase-related protein type 5 isoform X3

      Conserved Domains (1) summary
      cl00474
      Location:118 → 207
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    2. XM_036163381.1 → XP_036019274.1  phospholipid phosphatase-related protein type 5 isoform X4

      Conserved Domains (1) summary
      cl00474
      Location:118 → 208
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    3. XM_036163382.1 → XP_036019275.1  phospholipid phosphatase-related protein type 5 isoform X5

      Conserved Domains (1) summary
      cl00474
      Location:118 → 207
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    4. XM_036163379.1 → XP_036019272.1  phospholipid phosphatase-related protein type 5 isoform X2

      Conserved Domains (1) summary
      cd03384
      Location:118 → 266
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    5. XM_036163378.1 → XP_036019271.1  phospholipid phosphatase-related protein type 5 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPS1
      Conserved Domains (1) summary
      cd03384
      Location:118 → 267
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ52.1 GenPept UniProtKB/Swiss-Prot:Q8BJ52

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