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    CG6168 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6168provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036154
    Locus tag
    Dmel_CG6168
    See related
    AllianceGenome:FB:FBgn0036154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6168
    Summary
    Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in adult head. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase) and QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6168 in Genome Data Viewer
    Location:
    68C2-68C2; 3-36 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11319642..11321719, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11312742..11314819, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44361 Neighboring gene long non-coding RNA:CR46240 Neighboring gene long non-coding RNA:CR44721 Neighboring gene long non-coding RNA:CR44722 Neighboring gene long non-coding RNA:CR44723

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Schilling S, et al. Biochemistry, 2007 Sep 25. PMID 17722885
    2. Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster. Fiumera AC, et al. Genetics, 2007 Jun. PMID 17435238, Free PMC Article
    3. Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster. Ravi Ram K, et al. Proc Natl Acad Sci U S A, 2006 Dec 5. PMID 17116868, Free PMC Article
    4. Seminal fluid gene expression and reproductive fitness in Drosophila melanogaster. Patlar B, et al. BMC Ecol Evol, 2022 Feb 23. PMID 35196983, Free PMC Article
    5. Oh, the places they'll go: Female sperm storage and sperm precedence in Drosophila melanogaster. Schnakenberg SL, et al. Spermatogenesis, 2012 Jul 1. PMID 23087839, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6168-PB
    CG6168-PC
    NP_001287032.1
    NP_648459.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11319642..11321719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300103.1 → NP_001287032.1  uncharacterized protein Dmel_CG6168, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E739, Q9VTH7
      Conserved Domains (1) summary
      cd03880
      Location:49 → 330
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    2. NM_140202.2 → NP_648459.1  uncharacterized protein Dmel_CG6168, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E739, Q9VTH7
      Related
      FBpp0075912
      Conserved Domains (1) summary
      cd03880
      Location:49 → 330
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTH7 Q9VTH7

    Gene LinkOut

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