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    Gcat Glycine C-acetyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gcatprovided by FlyBase
    Official Full Name
    Glycine C-acetyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036208
    Locus tag
    Dmel_CG10361
    See related
    AllianceGenome:FB:FBgn0036208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10361; Dmel\CG10361; GCAT
    Summary
    Predicted to enable glycine C-acetyltransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in biosynthetic process and threonine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; larval somatic muscle cell; and sensory nervous system primordium. Orthologous to human GCAT (glycine C-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gcat in Genome Data Viewer
    Location:
    68E1-68E1; 3-37 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11798948..11800861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11792048..11793961, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 68D Neighboring gene transfer RNA:Glutamine-TTG 1-1 Neighboring gene Cubilin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1. Kizil C, et al. Mol Psychiatry, 2022 Jun. PMID 35365809, Free PMC Article
    2. Comparison of inter- and intraspecies variation in humans and fruit flies. Shih J, et al. Genom Data, 2015 Mar. PMID 26484147, Free PMC Article
    3. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
    4. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio. Lin WH, et al. J Neurogenet, 2018 Mar-Jun. PMID 29718742, Free PMC Article
    5. A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi. Fisher WW, et al. Genetics, 2023 Apr 6. PMID 36652461, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycine C-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycine C-acetyltransferase
    Names
    CG10361-PA
    Gcat-PA
    NP_648509.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11798948..11800861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140252.2 → NP_648509.1  glycine C-acetyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTN9
      Related
      FBpp0075815
      Conserved Domains (2) summary
      COG0156
      Location:30 → 410
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      PRK06939
      Location:19 → 416
      PRK06939; 2-amino-3-ketobutyrate coenzyme A ligase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXK3 Q8SXK3
    Q9VTN9 Q9VTN9

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